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Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer
Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile. The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA...
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Published in: | Journal of drug delivery science and technology 2023-09, Vol.87, p.104778, Article 104778 |
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container_start_page | 104778 |
container_title | Journal of drug delivery science and technology |
container_volume | 87 |
creator | Mahvash, Shahrzad Zavareh, Vajihe Azimian Taymouri, Somayeh Mirian, Mina Ramezani-Aliakbari, Maryam Dousti, Fatemeh Rostami, Mahboubeh |
description | Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile.
The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB-231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line.
The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100%, and the apoptosis value was higher (81%) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies.
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doi_str_mv | 10.1016/j.jddst.2023.104778 |
format | article |
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The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB-231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line.
The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100%, and the apoptosis value was higher (81%) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies.
[Display omitted]</description><identifier>ISSN: 1773-2247</identifier><identifier>DOI: 10.1016/j.jddst.2023.104778</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Anderson-type manganese polyoxomolybdate (MnMo6) ; Anticancer activity ; Apoptosis ; Cell migration ; Imidazolium modified chitosan (CSIm) ; Nanocomposite (NC)</subject><ispartof>Journal of drug delivery science and technology, 2023-09, Vol.87, p.104778, Article 104778</ispartof><rights>2023 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-63e6a4b0ec420febf20257f09f6e5a3f701981704844e3c9d11ac2e3a392dba83</citedby><cites>FETCH-LOGICAL-c303t-63e6a4b0ec420febf20257f09f6e5a3f701981704844e3c9d11ac2e3a392dba83</cites><orcidid>0000-0001-9968-821X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Mahvash, Shahrzad</creatorcontrib><creatorcontrib>Zavareh, Vajihe Azimian</creatorcontrib><creatorcontrib>Taymouri, Somayeh</creatorcontrib><creatorcontrib>Mirian, Mina</creatorcontrib><creatorcontrib>Ramezani-Aliakbari, Maryam</creatorcontrib><creatorcontrib>Dousti, Fatemeh</creatorcontrib><creatorcontrib>Rostami, Mahboubeh</creatorcontrib><title>Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer</title><title>Journal of drug delivery science and technology</title><description>Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile.
The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB-231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line.
The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100%, and the apoptosis value was higher (81%) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies.
[Display omitted]</description><subject>Anderson-type manganese polyoxomolybdate (MnMo6)</subject><subject>Anticancer activity</subject><subject>Apoptosis</subject><subject>Cell migration</subject><subject>Imidazolium modified chitosan (CSIm)</subject><subject>Nanocomposite (NC)</subject><issn>1773-2247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhbNQsNT-Ajf5A1Pz6jwWLkrxBQU3ug553NQMnWRIxuL8e1Pr2s09cOBczvkQuqNkTQmt7_t1b22e1owwXhzRNO0VWtCm4RVjorlBq5x7QghtCBWsW6CwDRZSjqGa5hHwoMJBBciAx3ic43ccimirJsCfs07e4qBCNHEYY_bFdDFhHWOefDhgm77KgaM_QZqxOigf8oR1AlXEqGAg3aJrp44ZVn-6RB9Pj--7l2r_9vy62-4rwwmfqppDrYQmYAQjDrQrezaNI52rYaO4K-27tmwQrRDATWcpVYYBV7xjVquWLxG__DUp5pzAyTH5QaVZUiLPpGQvf0nJMyl5IVVSD5cUlGonD0lm46H0tj6BmaSN_t_8D-d5eAc</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Mahvash, Shahrzad</creator><creator>Zavareh, Vajihe Azimian</creator><creator>Taymouri, Somayeh</creator><creator>Mirian, Mina</creator><creator>Ramezani-Aliakbari, Maryam</creator><creator>Dousti, Fatemeh</creator><creator>Rostami, Mahboubeh</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-9968-821X</orcidid></search><sort><creationdate>202309</creationdate><title>Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer</title><author>Mahvash, Shahrzad ; Zavareh, Vajihe Azimian ; Taymouri, Somayeh ; Mirian, Mina ; Ramezani-Aliakbari, Maryam ; Dousti, Fatemeh ; Rostami, Mahboubeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-63e6a4b0ec420febf20257f09f6e5a3f701981704844e3c9d11ac2e3a392dba83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anderson-type manganese polyoxomolybdate (MnMo6)</topic><topic>Anticancer activity</topic><topic>Apoptosis</topic><topic>Cell migration</topic><topic>Imidazolium modified chitosan (CSIm)</topic><topic>Nanocomposite (NC)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahvash, Shahrzad</creatorcontrib><creatorcontrib>Zavareh, Vajihe Azimian</creatorcontrib><creatorcontrib>Taymouri, Somayeh</creatorcontrib><creatorcontrib>Mirian, Mina</creatorcontrib><creatorcontrib>Ramezani-Aliakbari, Maryam</creatorcontrib><creatorcontrib>Dousti, Fatemeh</creatorcontrib><creatorcontrib>Rostami, Mahboubeh</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of drug delivery science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahvash, Shahrzad</au><au>Zavareh, Vajihe Azimian</au><au>Taymouri, Somayeh</au><au>Mirian, Mina</au><au>Ramezani-Aliakbari, Maryam</au><au>Dousti, Fatemeh</au><au>Rostami, Mahboubeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer</atitle><jtitle>Journal of drug delivery science and technology</jtitle><date>2023-09</date><risdate>2023</risdate><volume>87</volume><spage>104778</spage><pages>104778-</pages><artnum>104778</artnum><issn>1773-2247</issn><abstract>Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile.
The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB-231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line.
The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100%, and the apoptosis value was higher (81%) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies.
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subjects | Anderson-type manganese polyoxomolybdate (MnMo6) Anticancer activity Apoptosis Cell migration Imidazolium modified chitosan (CSIm) Nanocomposite (NC) |
title | Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer |
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