Therapeutic potential of GDNF in neuroinflammation: Targeted delivery approaches for precision treatment in neurological diseases

Neurological diseases represent a prevalent and severe category of diseases, affecting staggering 6.8 million individuals worldwide annually. These encompass neurodegenerative diseases such as AD, PD and ALS, as well as conditions like CNS injuries, stroke, epilepsy, and neuropathy, with diabetic ne...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2023-09, Vol.87, p.104876, Article 104876
Main Authors: Singh, Gurpreet, Sikder, Anupama, Phatale, Vivek, Srivastava, Saurabh, Singh, Shashi Bala, Khatri, Dharmendra Kumar
Format: Article
Language:English
Subjects:
GDNF delivery
Glial cells
Neuroinflammation
Neurological diseases
Therapeutic potential
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Summary:Neurological diseases represent a prevalent and severe category of diseases, affecting staggering 6.8 million individuals worldwide annually. These encompass neurodegenerative diseases such as AD, PD and ALS, as well as conditions like CNS injuries, stroke, epilepsy, and neuropathy, with diabetic neuropathy being the most prevalent form. Across all these diseases, a typical underlying process that governs their pathogenesis is neuroinflammation. Neuroinflammation arises in response to various stimuli, including β-amyloid and α-synuclein in the context of neurodegeneration, pathogens in the case of CNS infections, and ischemic conditions in stroke and CNS injuries. These stimuli activate PRRs on glial cells, initiating a neuroinflammatory response cascade. Among these responses, glial cells, including microglia and astrocytes, secrete GDNF, a prominent neurotrophic factor. GDNF exerts significant regulatory effects on neuroinflammation and has emerged as a therapeutic target for a wide range of drugs to mitigate neurological diseases. This review primarily focuses on elucidating the role of GDNF in neuroinflammation and exploring its therapeutic potential in treating neurological diseases. The challenges associated with delivering GDNF to the brain are discussed, along with advancements in GDNF delivery methods aimed at overcoming these obstacles to effectively treat neurological diseases. [Display omitted] •Neuroinflammation is a key factor in neurological diseases.•Glial cells play a role in neuroinflammatory conditions.•GDNF has therapeutic potential for controlling neuroinflammation.•Delivery advancements improve GDNF treatment for the neurological diseases.
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104876