A synoptic examination of commercially viable nanofiber-based products

• Published in: Journal of drug delivery science and technology 2024-12, Vol.102, p.106323, Article 106323
• Main Authors: Chaudhari, Divya R., Ramani, Vinod D., Shah, Dhiren P., Vaishnav, Devendra, Kapoor, Devesh U.
• Format: Article
• Language: English
• Subjects: Biomedicine; Commercialization; Drug delivery devices; Electrospun technology; Nanofibers; Scaffolds; Sensors; Wound dressings
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2024.106323

In the pharmaceutical field, drug delivery devices are promising tools because they maximize therapeutic effects while minimizing side effects. The biocompatibility and broad flexibility of electrospun nanofibers have attracted increasing attention in recent years. Electrospinning has been extensively studied recently due to its potential applications in various fields, particularly pharmaceuticals and biomedicine. Typical production rates are around 0.01–1 g/h, which is lower than the production requirements of the pharmaceutical industry. Therefore, many companies are developing electrospinning equipment, technological solutions, and large-scale production of electrospun materials. Review highlights the best properties of nanofibers, their fabrication techniques, and novel drug delivery approaches using electro spun technology in medical and healthcare applications. In the upcoming decades, electrospinning technology will move from being a scientific interdisciplinary research approach to a practice-based interdisciplinary approach in a variety of fields. This review delves into the applications of electrospun nanofibers in various medical fields, particularly focusing on their role in wound healing and the treatment of neurological and spinal conditions. Furthermore, the review explores significant advancements in the use of electrospun nanofibers in dentistry, highlighting their impact on implant modification, periodontal regeneration, jaw repair, and restorative treatments. In this article, progress on electrospun nanofiber commercialization is discussed as well as scalability issues related to electrospun nanofiber manufacturing. [Display omitted]