Electrochemical sensor for simultaneous determination of epinephrine and norepinephrine based on cetyltrimethylammonium bromide assisted SnO2 nanoparticles

A highly sensitive and selective electrochemical sensor has been developed for simultaneous determination of catecholamine neurotransmitters, epinephrine (EP) and norepinephrine (NEP) using cetyltrimethylammonium bromide (CTAB) assisted SnO2 nanoparticles (NPs) synthesized by microwave irradiation m...

Full description

Saved in:
Bibliographic Details
Published in:Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 2017-09, Vol.801, p.503-510
Main Authors: Lavanya, N., Sekar, C.
Format: Article
Language:English
Subjects:
Electrochemical sensor
Epinephrine
Neurotransmitters
Norepinephrine
SnO2 nanoparticles
Surfactant
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A highly sensitive and selective electrochemical sensor has been developed for simultaneous determination of catecholamine neurotransmitters, epinephrine (EP) and norepinephrine (NEP) using cetyltrimethylammonium bromide (CTAB) assisted SnO2 nanoparticles (NPs) synthesized by microwave irradiation method. The products were characterized by powder XRD, HRTEM, UV-visible absorption and FTIR spectroscopy and cyclic voltammetric methods. The CTAB-SnO2 NPs modified glassy carbon electrode (GCE) exhibited two sharp well defined reduction peaks for EP and NEP with a significant potential difference of 0.354 V in phosphate buffer solution (pH5.0). Under optimum conditions, the calibration curves for EP and NEP were obtained over a wide concentration range of 0.1–250 and 0.1–300μM with the lowest detection limits of 10 and 6nM for EP and NEP respectively. Interference studies showed that the modified electrodes have excellent selectivity towards EP and NEP in the presence of potential biological interferents uric acid and ascorbic acid. The proposed electrode has been successfully applied to the simultaneous determination of EP and NEP in human urine samples with satisfactory recoveries. [Display omitted] •A CTAB-SnO2 electrochemical sensor has been fabricated for simultaneous determination of epinephrine and norepinephrine.•The proposed sensor exhibits low detection limit (10 for EP and 19 nM for NEP), good stability and high reproducibility.•The fabricated sensor was successfully applied to the analysis of human urine samples with satisfactory results.
ISSN:1572-6657
1873-2569
DOI:10.1016/j.jelechem.2017.08.018