Progression of ECG in hydroxychloroquine overdose

Hydroxychloroquine overdose is associated with myocardial toxicity and conduction disorders. We report a case of hydroxychloroquine overdose that demonstrated a rapid progressive intraventricular conduction delay and QT prolongation resulting in significant bradycardia and shock despite aggressive t...

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Bibliographic Details
Published in:Journal of electrocardiology 2023-03, Vol.77, p.68-71
Main Authors: Thaper, Arushi, Ross, Steven J., Agarwal, Zubin, Langston, Michael, Miles, William M., Austin, Adam
Format: Article
Language:English
Subjects:
Bradycardia - chemically induced
Bradycardia - diagnosis
Cardiac toxicity
Drug Overdose - diagnosis
Drug Overdose - drug therapy
Electrocardiography
Humans
Hydroxychloroquine
Hydroxychloroquine - therapeutic use
Long QT Syndrome - drug therapy
Overdose
QRS prolongation
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Summary:Hydroxychloroquine overdose is associated with myocardial toxicity and conduction disorders. We report a case of hydroxychloroquine overdose that demonstrated a rapid progressive intraventricular conduction delay and QT prolongation resulting in significant bradycardia and shock despite aggressive treatment. We describe the rare capture of abrupt abnormalities of this overdose in sequential electrocardiograms in the immediate hours post-ingestion.
ISSN:0022-0736
1532-8430
DOI:10.1016/j.jelectrocard.2023.01.002