Diethylene Glycol: Widely Used Solvent Presents Serious Poisoning Potential

Abstract Objective: To describe the serious toxicity of a readily available solvent, diethylene glycol (DEG). We describe a case of intentional ingestion of a wallpaper stripper containing DEG resulting in severe multi-system organ failure. Case Report: A 27-year-old male presented to the Emergency...

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Bibliographic Details
Published in:The Journal of emergency medicine 2008-11, Vol.35 (4), p.401-406
Main Authors: Marraffa, Jeanna M., PHARMD, DABAT, Holland, Michael G., MD, Stork, Christine M., PHARMD, DABAT, Hoy, Christopher D., MD, Hodgman, Michael J., MD
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - therapy
Adult
Diagnosis, Differential
Emergency
Ethylene Glycols - poisoning
Humans
Male
Poisoning - diagnosis
Poisoning - therapy
Renal Dialysis
Solvents - poisoning
Suicide, Attempted
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Summary:Abstract Objective: To describe the serious toxicity of a readily available solvent, diethylene glycol (DEG). We describe a case of intentional ingestion of a wallpaper stripper containing DEG resulting in severe multi-system organ failure. Case Report: A 27-year-old male presented to the Emergency Department (ED) one day after ingesting wallpaper stripper containing DEG. He developed acidosis, renal cortical necrosis, hepatocellular injury, and severe neurologic sequelae, including cranial neuropathies and peripheral demyelinating sensori-motor polyneuropathy. His neurologic function improved over 5 months. Discussion: Our case demonstrates the severe toxicity of DEG. DEG is present in numerous formulations, often without proper protective packaging. DEG has been associated with severe epidemic poisonings in the past and with the availability of safer alternatives, DEG in consumer products should be eliminated. Conclusion: DEG is found in numerous products. Delays in treatment can have devastating results, resulting in death or permanent disability. The pervasive use of this compound makes further human exposures likely.
ISSN:0736-4679
DOI:10.1016/j.jemermed.2007.06.025