Anti-diabetic effect on alloxanized and normoglycemic rats and some pharmacological evaluations of Tournefortia hartwegiana

The purpose of the present investigation was to assess the pharmacological properties of Tournefortia hartwegiana Steud (Boraginaceae), used in traditional medicine for the treatment of diabetes, diarrhea and kidney pain in Morelos, Mexico. Administration of methanol extract from aerial parts of Tou...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2005-10, Vol.101 (1), p.37-42
Main Authors: Ortiz-Andrade, R.R., Rodríguez-López, V., Garduño-Ramírez, M.L., Castillo-España, P., Estrada-Soto, S.
Format: Article
Language:English
Subjects:
Alloxan
Alloxan diabetic rats
Animals
bioassays
Biological and medical sciences
Boraginaceae
chemical constituents of plants
Diabetes
diabetes mellitus
Diabetes Mellitus, Experimental - drug therapy
ethnobotany
General pharmacology
herbal medicines
hypoglycemic agents
Hypoglycemic Agents - therapeutic use
Male
Medical sciences
medicinal plants
medicinal properties
Mexico
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
plant extracts
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Tournefortia
Tournefortia hartwegiana
traditional medicine
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Summary:The purpose of the present investigation was to assess the pharmacological properties of Tournefortia hartwegiana Steud (Boraginaceae), used in traditional medicine for the treatment of diabetes, diarrhea and kidney pain in Morelos, Mexico. Administration of methanol extract from aerial parts of Tournefortia hartwegiana (310 mg/kg body weight/day) for 10 days, to normoglycemic and alloxan-induced diabetic rats, significantly lowered their blood glucose levels (37 and 36%, respectively, p < 0.05). The anti-diabetic and hypoglycemic activities due to the MeOH extract were similar to those produced by metformin at 120 mg/kg (positive control, p < 0.05). In contrast, the hexane, dichloromethane and MeOH extracts from the same species showed no significant spasmolytic effect and did not have activity in antibacterial and Artemia salina toxicity bioassays.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2005.03.022