Hepatoprotective studies on Hedyotis corymbosa (L.) Lam

Hedyotis corymbosa is used in traditional medicine of India and China to treat various hepatic disorders. In the present study, the hepatoprotective effect of the methanolic extract of the whole plant of Hedyotis corymbosa against paracetamol overdose-induced liver damage in Wistar rats was studied....

Full description

Saved in:
Bibliographic Details
Published in:Journal of ethnopharmacology 2006-06, Vol.106 (2), p.245-249
Main Authors: Sadasivan, Sini, Latha, P.G., Sasikumar, J.M., Rajashekaran, S., Shyamal, S., Shine, V.J.
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Analgesics, Non-Narcotic - administration & dosage
Animals
Antilipid peroxidation
Biological and medical sciences
Chemical and Drug Induced Liver Injury
Dose-Response Relationship, Drug
Drug Overdose
General pharmacology
Hedyotis
Hedyotis corymbosa
Hexobarbital - administration & dosage
Hexobarbitone
Histology
Hypnotics and Sedatives - administration & dosage
Lipid Peroxidation
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver Diseases - pathology
Liver Diseases - prevention & control
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Protective Agents - pharmacology
Protective Agents - therapeutic use
Rats
Rats, Wistar
Serum enzyme activities
Silymarin - pharmacology
Sleep - drug effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hedyotis corymbosa is used in traditional medicine of India and China to treat various hepatic disorders. In the present study, the hepatoprotective effect of the methanolic extract of the whole plant of Hedyotis corymbosa against paracetamol overdose-induced liver damage in Wistar rats was studied. The methanolic extract of the plant produced significant hepatoprotective effects as evidenced by decreased serum enzyme activities, SGPT, SGOT, SAKP and serum bilirubin and an almost normal histological architecture of the liver, in treated groups, compared to the controls. Hedyotis corymbosa shortened hexobarbitone-induced sleeping time in mice, besides showing significant antilipid peroxidant effect in vitro. The results thus support the use of Hedyotis corymbosa as a hepatoprotective agent.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2006.01.002