Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays

Total rhubarb anthraquinones (TRAs) are the active therapeutic components from the rhizomes of Rheum palmatum L. (Polygonaceae), which are widely used in traditional Chinese medicines (TCMs) and have been reported to have cell toxicity recently. This study focuses on the toxicity of TRAs on Sprague...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2006-09, Vol.107 (2), p.308-311
Main Authors: Yan, Ming, Zhang, Lu-Yong, Sun, Li-Xin, Jiang, Zhen-Zhou, Xiao, Xiao-He
Format: Article
Language:English
Subjects:
Animals
anthraquinones
Anthraquinones - isolation & purification
Anthraquinones - toxicity
Biological and medical sciences
chemical constituents of plants
Cytochrome P-450 CYP1A1 - genetics
DNA
Epithelial Cells - drug effects
Epithelial Cells - enzymology
Epithelial Cells - metabolism
Epithelial Cells - pathology
ethnobotany
Gene Expression Regulation - drug effects
General pharmacology
herbal medicines
Kidney - drug effects
Kidney - enzymology
Kidney - metabolism
Kidney - pathology
Kidney Tubules - drug effects
Kidney Tubules - enzymology
Kidney Tubules - metabolism
Kidney Tubules - pathology
MAP Kinase Kinase Kinases - genetics
Medical sciences
medicinal properties
microarray technology
mitogen-activated protein kinase
Mutagens - isolation & purification
Mutagens - toxicity
nephrotoxicity
Oligonucleotide Array Sequence Analysis
Oligonucleotide microarrays
Oriental traditional medicine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
plant extracts
Rats
Rats, Sprague-Dawley
Rheum - chemistry
Rheum - toxicity
Rheum palmatum
Rhizome - chemistry
Rhizome - toxicity
rhizomes
rhubarb
RNA - genetics
Total rhubarb anthroquinones
Toxicogenomics
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Summary:Total rhubarb anthraquinones (TRAs) are the active therapeutic components from the rhizomes of Rheum palmatum L. (Polygonaceae), which are widely used in traditional Chinese medicines (TCMs) and have been reported to have cell toxicity recently. This study focuses on the toxicity of TRAs on Sprague Dawley (S.D.) rats. TRAs administrated per os for 13 weeks induced nephrotoxicity on S.D. rats as renal tubule epithelial cells swelled and denatured in tissue slice examination. After high-density oligonucleotide microarrays scanning, we have identified mitogen-activated protein kinase (MAPK) kinase 6 to be the target gene which causes cell cycle arrest and proliferation inhibition and contributes to nephrotoxicity on S.D. rats.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2006.03.031