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Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice
Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant Plasmodium berghei NK65, either alone or in combination with CQ. The plant parts...
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Published in: | Journal of ethnopharmacology 2007-04, Vol.111 (1), p.190-195 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their
in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant
Plasmodium berghei NK65, either alone or in combination with CQ. The plant parts used ranged from leaves (L), stem bark (SB), root bark (RB), seeds (S) and whole plant (W). When used alone, extracts from seven plants,
Clerodendrum myricoides (RB),
Ficus sur (L/SB/RB),
Maytenus acuminata (L/RB),
Rhamnus prinoides (L/RB),
Rhamnus staddo (RB),
Toddalia asiatica (RB) and
Vernonia lasiopus (RB) had statistically significant parasitaemia suppressions of 31.7–59.3%. In combination with CQ, methanolic extracts of
Albizia gummifera (SB),
Ficus sur (RB),
Rhamnus prinoides and
Rhamnus staddo (L/RB),
Caesalpinia volkensii (L),
Maytenus senegalensis (L/RB),
Withania somnifera (RB),
Ekebergia capensis (L/SB),
Toddalia asiatica (L/RB) and
Vernonia lasiopus (L/SB/RB) gave statistically significant and improved suppressions which ranged from 45.5 to 85.1%. The fact that these activities were up to five-fold higher than that of extract alone may suggest synergistic interactions. Remarkable parasitaemia suppression by the extracts, either alone or in combination with CQ mostly resulted into longer mouse survival relative to the controls, in some cases by a further 2 weeks. Plants, which showed significant antimalarial activity including
Vernonia lasiopus,
Toddalia asiatica,
Ficus sur,
Rhamnus prinoides and
Rhamnus staddo warrant further evaluation in the search for novel antimalarial agents against drug-resistant malaria. |
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ISSN: | 0378-8741 1872-7573 |
DOI: | 10.1016/j.jep.2006.11.009 |