The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities

• Published in: Journal of ethnopharmacology 2009-04, Vol.122 (3), p.555-560
• Main Authors: Shen, Xiangchun, Tang, Yuping, Yang, Ruihui, Yu, Li, Fang, Taihui, Duan, Jin-ao
• Format: Article
• Language: English
• Subjects: alanine transaminase; Alanine Transaminase - blood; animal disease models; Animals; antioxidant activity; Antioxidants - pharmacology; Antioxidants - therapeutic use; Aspartate Aminotransferases - blood; aspartate transaminase; Biological and medical sciences; biomarkers; Biphenyl Compounds - pharmacology; carbon tetrachloride; Carbon Tetrachloride Poisoning; catalase; Catalase - metabolism; CCl 4; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; dosage; Dose-Response Relationship, Drug; enzyme activity; ethanol; Fruit; fruit extracts; General pharmacology; glutathione; Glutathione - metabolism; glutathione peroxidase; Glutathione Peroxidase - metabolism; Hepatic injury; hepatoprotective effect; histopathology; lipid peroxidation; Lipid Peroxidation - drug effects; liver; Liver - metabolism; Liver - pathology; Medical sciences; medicinal plants; Mice; Mice, Inbred ICR; Oriental traditional medicine; Oxidative stress; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Protective Agents - pharmacology; Protective Agents - therapeutic use; superoxide dismutase; Superoxide Dismutase - metabolism; Ziziphus; Ziziphus jujuba; Zizyphus jujube
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2009.01.027

The study was aimed to investigate the protective effect against hepatic injury induced by CCl 4 for the ethanolic extract of FZJ. The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarker in blood of hepatic injury. Product of lipid peroxidation (MDA), activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed at the degree of hepatic injury. After administrated the FZJ, the dose of 200 mg/kg significantly decreased ALT and AST, and attenuated histopathology of hepatic injury, and ameliorated the oxidative stress in hepatic tissue. Partly assayed indexes were ameliorated after administrated FZJ at the dose of 100 mg/kg. These results indicated that hepatic protective effects of FZJ were very relevant to modulate the oxidative stress in hepatic injury.