Pharmacological evaluation of Ipomoea asarifolia (Desr.) against carbon tetrachloride-induced hepatotoxicity in rats

Ipomoeaasarifolia (Desr.) Roem. and Schult. is used traditionally in some parts of Africa for the treatment of a variety of diseases. This study attempts to validate its hepatoprotective activity by evaluating the prophylactic and curative properties of the methanolic extract of Ipomoea asarifolia (...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2012-08, Vol.142 (3), p.642-646
Main Authors: Farida, T., Salawu, O.A., Tijani, A.Y., Ejiofor, J.I.
Format: Article
Language:English
Subjects:
alanine transaminase
Alanine Transaminase - blood
alkaline phosphatase
Alkaline Phosphatase - blood
Animals
Aspartate Aminotransferases - blood
aspartate transaminase
Bilirubin - blood
Carbon Tetrachloride
Carbon tetrachloride (CCl4)
Chemical and Drug Induced Liver Injury - blood
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - pathology
cholesterol
Cholesterol - blood
Convolvulaceae
drugs
Female
Hepatoprotective activity
hepatoprotective effect
hepatotoxicity
histopathology
Ipomoea
Ipomoea asarifolia
leaves
liver
Liver damage
Male
olive oil
Organ Size - drug effects
Phytotherapy
plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves - chemistry
Protective Agents - chemistry
Protective Agents - pharmacology
Protective Agents - therapeutic use
Rats
Rats, Wistar
silymarin
triacylglycerols
Triglycerides - blood
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Summary:Ipomoeaasarifolia (Desr.) Roem. and Schult. is used traditionally in some parts of Africa for the treatment of a variety of diseases. This study attempts to validate its hepatoprotective activity by evaluating the prophylactic and curative properties of the methanolic extract of Ipomoea asarifolia (IA) leaves. Liver damage was induced by administering 0.5ml/kg of an equal mixture of carbon tetrachloride (CCl4) in olive oil intraperitoneally on alternate days, for 5 days and the plant extract was given orally daily, for 7 days at doses of 100, 200 and 400mg/kg. Pre-treatment with the extract significantly (P
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2012.05.029