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Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS
Prosthechea karwinskii (Mart.) J.M.H. Shaw is a Mexican orchid used in traditional medicine by some indigenous communities to treat issues related to inflammation (cough, wounds, burns, and diabetes). Pharmacological research of this orchid could validate its therapeutic uses and demonstrate its pot...
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Published in: | Journal of ethnopharmacology 2020-05, Vol.253, p.112632, Article 112632 |
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creator | Barragán-Zarate, Gabriela Soledad Lagunez-Rivera, Luicita Solano, Rodolfo Pineda-Peña, Elizabeth Arlen Landa-Juárez, Arizai Yolia Chávez-Piña, Aracely Evangelina Carranza-Álvarez, Candy Hernández-Benavides, Diego Manuel |
description | Prosthechea karwinskii (Mart.) J.M.H. Shaw is a Mexican orchid used in traditional medicine by some indigenous communities to treat issues related to inflammation (cough, wounds, burns, and diabetes). Pharmacological research of this orchid could validate its therapeutic uses and demonstrate its potential for treating other health conditions of high prevalence in Mexico, including those associated with oxidative stress such as diabetes, cancer, atherosclerosis, and hypertension as well as inflammation.
The leaf extract from P. karwinskii was examined to identify its compounds and elucidate its inhibitory effect on reactive oxygen species as well as its anti-inflammatory activity and gastroprotective effects in an animal model.
Compounds were identified via ultra-high-performance liquid chromatography coupled with electrospray ionization with quadrupole time of flight-mass spectrometry. Inhibition of reactive oxygen species was determined ex vivo in peripheral blood mononuclear cells with 2′,7′-dichlorodihydrofluorescein diacetate. The anti-inflammatory activity was assessed using a carrageenan-induced paw edema model in Wistar rats; nitric oxide and tumor necrosis factor alpha levels were quantified. The gastroprotective effect was evaluated in Wistar rats with indomethacin-induced gastric injury.
Nine compounds were identified in the P. karwinskii leaf extract. Most compounds, such as quinic acid, malic acid, neochlorogenic acid, chlorogenic acid, rutin, embelin, pinellic acid, and azelaic acid, were reported to exhibit antioxidant and/or anti-inflammatory activity. The extract was also found to inhibit reactive oxygen species in the ex vivo model. Unlike other anti-inflammatory drugs, the extract exerted a dual effect: anti-inflammatory activity and protection of the gastric mucosa. The results showed that the extract could significantly inhibit the release of nitric oxide without a dose-response relationship.
P. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discove |
doi_str_mv | 10.1016/j.jep.2020.112632 |
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The leaf extract from P. karwinskii was examined to identify its compounds and elucidate its inhibitory effect on reactive oxygen species as well as its anti-inflammatory activity and gastroprotective effects in an animal model.
Compounds were identified via ultra-high-performance liquid chromatography coupled with electrospray ionization with quadrupole time of flight-mass spectrometry. Inhibition of reactive oxygen species was determined ex vivo in peripheral blood mononuclear cells with 2′,7′-dichlorodihydrofluorescein diacetate. The anti-inflammatory activity was assessed using a carrageenan-induced paw edema model in Wistar rats; nitric oxide and tumor necrosis factor alpha levels were quantified. The gastroprotective effect was evaluated in Wistar rats with indomethacin-induced gastric injury.
Nine compounds were identified in the P. karwinskii leaf extract. Most compounds, such as quinic acid, malic acid, neochlorogenic acid, chlorogenic acid, rutin, embelin, pinellic acid, and azelaic acid, were reported to exhibit antioxidant and/or anti-inflammatory activity. The extract was also found to inhibit reactive oxygen species in the ex vivo model. Unlike other anti-inflammatory drugs, the extract exerted a dual effect: anti-inflammatory activity and protection of the gastric mucosa. The results showed that the extract could significantly inhibit the release of nitric oxide without a dose-response relationship.
P. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternative therapies for inflammatory disorders.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2020.112632</identifier><identifier>PMID: 31991201</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Anti-inflammatory ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - toxicity ; DCFH-DA ; Disease Models, Animal ; Edema - drug therapy ; Edema - pathology ; Female ; Gastric Mucosa - drug effects ; Gastric Mucosa - pathology ; Gastroprotection ; Humans ; Inflammation - drug therapy ; Inflammation - pathology ; Leukocytes, Mononuclear - drug effects ; Nitric Oxide - metabolism ; Orchidaceae ; Orchidaceae - chemistry ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Plant Leaves ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; UPLC-ESI-qTOF-MS/MS</subject><ispartof>Journal of ethnopharmacology, 2020-05, Vol.253, p.112632, Article 112632</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-f9f12ddff7f54dce4041695ada457dcc88b2f5755c0f18a7a71bb9a640c0bc173</citedby><cites>FETCH-LOGICAL-c353t-f9f12ddff7f54dce4041695ada457dcc88b2f5755c0f18a7a71bb9a640c0bc173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31991201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barragán-Zarate, Gabriela Soledad</creatorcontrib><creatorcontrib>Lagunez-Rivera, Luicita</creatorcontrib><creatorcontrib>Solano, Rodolfo</creatorcontrib><creatorcontrib>Pineda-Peña, Elizabeth Arlen</creatorcontrib><creatorcontrib>Landa-Juárez, Arizai Yolia</creatorcontrib><creatorcontrib>Chávez-Piña, Aracely Evangelina</creatorcontrib><creatorcontrib>Carranza-Álvarez, Candy</creatorcontrib><creatorcontrib>Hernández-Benavides, Diego Manuel</creatorcontrib><title>Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Prosthechea karwinskii (Mart.) J.M.H. Shaw is a Mexican orchid used in traditional medicine by some indigenous communities to treat issues related to inflammation (cough, wounds, burns, and diabetes). Pharmacological research of this orchid could validate its therapeutic uses and demonstrate its potential for treating other health conditions of high prevalence in Mexico, including those associated with oxidative stress such as diabetes, cancer, atherosclerosis, and hypertension as well as inflammation.
The leaf extract from P. karwinskii was examined to identify its compounds and elucidate its inhibitory effect on reactive oxygen species as well as its anti-inflammatory activity and gastroprotective effects in an animal model.
Compounds were identified via ultra-high-performance liquid chromatography coupled with electrospray ionization with quadrupole time of flight-mass spectrometry. Inhibition of reactive oxygen species was determined ex vivo in peripheral blood mononuclear cells with 2′,7′-dichlorodihydrofluorescein diacetate. The anti-inflammatory activity was assessed using a carrageenan-induced paw edema model in Wistar rats; nitric oxide and tumor necrosis factor alpha levels were quantified. The gastroprotective effect was evaluated in Wistar rats with indomethacin-induced gastric injury.
Nine compounds were identified in the P. karwinskii leaf extract. Most compounds, such as quinic acid, malic acid, neochlorogenic acid, chlorogenic acid, rutin, embelin, pinellic acid, and azelaic acid, were reported to exhibit antioxidant and/or anti-inflammatory activity. The extract was also found to inhibit reactive oxygen species in the ex vivo model. Unlike other anti-inflammatory drugs, the extract exerted a dual effect: anti-inflammatory activity and protection of the gastric mucosa. The results showed that the extract could significantly inhibit the release of nitric oxide without a dose-response relationship.
P. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternative therapies for inflammatory disorders.
[Display omitted]</description><subject>Animals</subject><subject>Anti-inflammatory</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - toxicity</subject><subject>DCFH-DA</subject><subject>Disease Models, Animal</subject><subject>Edema - drug therapy</subject><subject>Edema - pathology</subject><subject>Female</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastroprotection</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - pathology</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Nitric Oxide - metabolism</subject><subject>Orchidaceae</subject><subject>Orchidaceae - chemistry</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - toxicity</subject><subject>Plant Leaves</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>UPLC-ESI-qTOF-MS/MS</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kElPwzAQhS0EoqXwA7gg_4CmeLLUiTihik1CKmI5W44XZbokle0W-u9xFeDIaWak957mfYRcApsAg-n1YrIwm0nK0nhDOs3SIzKEkqcJL3h2TIYs42VS8hwG5Mz7BWOMQ85OySCDqoKUwZC4F9f50BjVGEmX0n1i65eIYypb2jnVoKZbbzSVngYnNQbsWrmia6NRYWvG1HwZF3yUB0ywtSu5XsvQuT2VKuAOQ1xaTbFtsMaoe52_nZMTK1feXPzMEfm4v3ufPSbP84en2e1zorIiC4mtLKRaW8ttkWtlcpbDtCqklnnBtVJlWae24EWhmIVScsmhris5zZlitQKejQj0uSpW9M5YsXG4lm4vgIkDP7EQkZ848BM9v-i56j2bbR07_jl-gUXBTS8w8fMdGie8QtOqyMMZFYTu8J_4b5M_gvU</recordid><startdate>20200510</startdate><enddate>20200510</enddate><creator>Barragán-Zarate, Gabriela Soledad</creator><creator>Lagunez-Rivera, Luicita</creator><creator>Solano, Rodolfo</creator><creator>Pineda-Peña, Elizabeth Arlen</creator><creator>Landa-Juárez, Arizai Yolia</creator><creator>Chávez-Piña, Aracely Evangelina</creator><creator>Carranza-Álvarez, Candy</creator><creator>Hernández-Benavides, Diego Manuel</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200510</creationdate><title>Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS</title><author>Barragán-Zarate, Gabriela Soledad ; 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J.M.H. Shaw is a Mexican orchid used in traditional medicine by some indigenous communities to treat issues related to inflammation (cough, wounds, burns, and diabetes). Pharmacological research of this orchid could validate its therapeutic uses and demonstrate its potential for treating other health conditions of high prevalence in Mexico, including those associated with oxidative stress such as diabetes, cancer, atherosclerosis, and hypertension as well as inflammation.
The leaf extract from P. karwinskii was examined to identify its compounds and elucidate its inhibitory effect on reactive oxygen species as well as its anti-inflammatory activity and gastroprotective effects in an animal model.
Compounds were identified via ultra-high-performance liquid chromatography coupled with electrospray ionization with quadrupole time of flight-mass spectrometry. Inhibition of reactive oxygen species was determined ex vivo in peripheral blood mononuclear cells with 2′,7′-dichlorodihydrofluorescein diacetate. The anti-inflammatory activity was assessed using a carrageenan-induced paw edema model in Wistar rats; nitric oxide and tumor necrosis factor alpha levels were quantified. The gastroprotective effect was evaluated in Wistar rats with indomethacin-induced gastric injury.
Nine compounds were identified in the P. karwinskii leaf extract. Most compounds, such as quinic acid, malic acid, neochlorogenic acid, chlorogenic acid, rutin, embelin, pinellic acid, and azelaic acid, were reported to exhibit antioxidant and/or anti-inflammatory activity. The extract was also found to inhibit reactive oxygen species in the ex vivo model. Unlike other anti-inflammatory drugs, the extract exerted a dual effect: anti-inflammatory activity and protection of the gastric mucosa. The results showed that the extract could significantly inhibit the release of nitric oxide without a dose-response relationship.
P. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternative therapies for inflammatory disorders.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31991201</pmid><doi>10.1016/j.jep.2020.112632</doi></addata></record> |
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subjects | Animals Anti-inflammatory Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - toxicity DCFH-DA Disease Models, Animal Edema - drug therapy Edema - pathology Female Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastroprotection Humans Inflammation - drug therapy Inflammation - pathology Leukocytes, Mononuclear - drug effects Nitric Oxide - metabolism Orchidaceae Orchidaceae - chemistry Oxidative stress Oxidative Stress - drug effects Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - toxicity Plant Leaves Rats Rats, Wistar Reactive Oxygen Species - metabolism UPLC-ESI-qTOF-MS/MS |
title | Prosthechea karwinskii, an orchid used as traditional medicine, exerts anti-inflammatory activity and inhibits ROS |
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