Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models

Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandr...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2020-10, Vol.260, p.113058, Article 113058
Main Authors: Zhang, Zhen-Biao, Ip, Siu-Po, Cho, William Chi, Hu, Zhen, Huang, Yan-Feng, Luo, Dan-Dan, Xian, Yan-Fang, Lin, Zhi-Xiu
Format: Article
Language:English
Subjects:
Androgen receptor
Androgen Receptor Antagonists - pharmacology
Androgen Receptor Antagonists - toxicity
Androgens - pharmacology
Androgens - toxicity
Animals
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - toxicity
Cell Line, Tumor
Cell Proliferation - drug effects
Chinese herbal medicine
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - toxicity
Gene Expression Regulation, Neoplastic
Humans
Male
Mice, Nude
Phytoandrogens
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Receptors, Androgen - drug effects
Receptors, Androgen - genetics
Receptors, Androgen - metabolism
Signal Transduction
Tumor Burden - drug effects
Xenograft Model Antitumor Assays
Xenograph
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Summary:Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandrogens. This study aimed to investigate the effects of the selected 21 Chinese herbal medicines on the proliferation and tumor growth using the relevant in vitro and in vivo models of PCa. After treatment of LNCaP and 22Rv1 cells with different concentrations of 70% ethanol extracts of the 21 selected herbal medicines for 48 h, the proliferative activity, the effects on androgen receptor (AR) and prostate specific antigen (PSA) were determined. The anti-tumor effects of the 21 herbs on PCa growth were also investigated on a subcutaneous mouse model of PCa. The results showed that Epimedii Folium (EF) and Codonopsis Radix (CNR) could significantly increase the cell viability in LNCaP cells (p 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2020.113058