Loading…
Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models
Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandr...
Saved in:
| Published in: | Journal of ethnopharmacology 2020-10, Vol.260, p.113058, Article 113058 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3 |
| container_end_page | |
| container_issue | |
| container_start_page | 113058 |
| container_title | Journal of ethnopharmacology |
| container_volume | 260 |
| creator | Zhang, Zhen-Biao Ip, Siu-Po Cho, William Chi Hu, Zhen Huang, Yan-Feng Luo, Dan-Dan Xian, Yan-Fang Lin, Zhi-Xiu |
| description | Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandrogens.
This study aimed to investigate the effects of the selected 21 Chinese herbal medicines on the proliferation and tumor growth using the relevant in vitro and in vivo models of PCa.
After treatment of LNCaP and 22Rv1 cells with different concentrations of 70% ethanol extracts of the 21 selected herbal medicines for 48 h, the proliferative activity, the effects on androgen receptor (AR) and prostate specific antigen (PSA) were determined. The anti-tumor effects of the 21 herbs on PCa growth were also investigated on a subcutaneous mouse model of PCa.
The results showed that Epimedii Folium (EF) and Codonopsis Radix (CNR) could significantly increase the cell viability in LNCaP cells (p |
| doi_str_mv | 10.1016/j.jep.2020.113058 |
| format | article |
| fullrecord | <record><control><sourceid>elsevier_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1016_j_jep_2020_113058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874120303056</els_id><sourcerecordid>S0378874120303056</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3</originalsourceid><addsrcrecordid>eNp9kE1OwzAQhS0EoqVwADbIF0ix4zhOxApV5UeqxAbWluNMGkdtHNlugUtwZhwFWLIazei9p3kfQteULCmh-W237GBYpiSNO2WEFydoTguRJoILdormhIkiKURGZ-jC-44QImhGztGMpTzlJC_m6Gt9VLuDCsb22DY4tIChaUAHP66qr53dQm80XrWmBw-4BVepHd5DbfR4wdH4K8MONAzBOj-ecDjsrcNbZ99Di02P4WMAZ_bQhxgwOOuDCoC16jU4vLc17PwlOmvUzsPVz1ygt4f16-op2bw8Pq_uN4lmnIWkSnOuRAmkUkCzkpQ8y7hWZa2FKNnYnlWVakhTEJ3XVVkqytOyyJs0pyz-yBaITrk6vuEdNHKInyn3KSmRI1vZychWjmzlxDZ6bibPcKhi_T_HL8wouJsEsQgcDTjptYHYrjYRTJC1Nf_EfwNpJY0I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models</title><source>Elsevier</source><creator>Zhang, Zhen-Biao ; Ip, Siu-Po ; Cho, William Chi ; Hu, Zhen ; Huang, Yan-Feng ; Luo, Dan-Dan ; Xian, Yan-Fang ; Lin, Zhi-Xiu</creator><creatorcontrib>Zhang, Zhen-Biao ; Ip, Siu-Po ; Cho, William Chi ; Hu, Zhen ; Huang, Yan-Feng ; Luo, Dan-Dan ; Xian, Yan-Fang ; Lin, Zhi-Xiu</creatorcontrib><description><![CDATA[Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandrogens.
This study aimed to investigate the effects of the selected 21 Chinese herbal medicines on the proliferation and tumor growth using the relevant in vitro and in vivo models of PCa.
After treatment of LNCaP and 22Rv1 cells with different concentrations of 70% ethanol extracts of the 21 selected herbal medicines for 48 h, the proliferative activity, the effects on androgen receptor (AR) and prostate specific antigen (PSA) were determined. The anti-tumor effects of the 21 herbs on PCa growth were also investigated on a subcutaneous mouse model of PCa.
The results showed that Epimedii Folium (EF) and Codonopsis Radix (CNR) could significantly increase the cell viability in LNCaP cells (p < 0.05 for both) and 22Rv1 cells (p < 0.05 for both), protein expressions of AR in LNCaP cells (p < 0.05 for both) and 22Rv1 cells (p < 0.05 for both), and PSA (p < 0.05 for both) in LNCaP cells. EF, CNR, and Cistanches Herba (CCH) markedly accentuated the tumor growth (p < 0.05 for three drugs) and AR expression (p < 0.05 for three herbs) in tumor tissues. On the other hand, treatment with Astragali Radix (AGR), Chuanxiong Rhizoma (CXR) and Bruceae Fructus (BF) significantly inhibited the cell viability in LNCaP cells (p < 0.05, p < 0.05 and p < 0.001, respectively) and in 22Rv1 cells (p < 0.05, p < 0.05 and p < 0.001, respectively), and the protein expression of AR in LNCaP cells (p < 0.05 for three herbs) and 22Rv1 cells (p < 0.05, p < 0.05 and p < 0.001, respectively), and the protein expression of PSA (p < 0.05 for three herbs) in LNCaP cells, as well as tumor growth (p < 0.05 for three herbs) and the AR expression (p < 0.05 for AGR and CXR, p < 0.001 for BF) in tumor tissues.
Our results revealed that AGR, CXR and BF suppressed the PCa development via inhibition of AR expression, while EF, CNR and CCH promoted the development and progression of PCa via enhancement of AR expression. The results strongly suggest that caution should be exercised when using androgenic Chinese herbal medicines in PCa patients.
[Display omitted]]]></description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2020.113058</identifier><identifier>PMID: 32525068</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Androgen receptor ; Androgen Receptor Antagonists - pharmacology ; Androgen Receptor Antagonists - toxicity ; Androgens - pharmacology ; Androgens - toxicity ; Animals ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - toxicity ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chinese herbal medicine ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - toxicity ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Nude ; Phytoandrogens ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Receptors, Androgen - drug effects ; Receptors, Androgen - genetics ; Receptors, Androgen - metabolism ; Signal Transduction ; Tumor Burden - drug effects ; Xenograft Model Antitumor Assays ; Xenograph</subject><ispartof>Journal of ethnopharmacology, 2020-10, Vol.260, p.113058, Article 113058</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3</citedby><cites>FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32525068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhen-Biao</creatorcontrib><creatorcontrib>Ip, Siu-Po</creatorcontrib><creatorcontrib>Cho, William Chi</creatorcontrib><creatorcontrib>Hu, Zhen</creatorcontrib><creatorcontrib>Huang, Yan-Feng</creatorcontrib><creatorcontrib>Luo, Dan-Dan</creatorcontrib><creatorcontrib>Xian, Yan-Fang</creatorcontrib><creatorcontrib>Lin, Zhi-Xiu</creatorcontrib><title>Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description><![CDATA[Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandrogens.
This study aimed to investigate the effects of the selected 21 Chinese herbal medicines on the proliferation and tumor growth using the relevant in vitro and in vivo models of PCa.
After treatment of LNCaP and 22Rv1 cells with different concentrations of 70% ethanol extracts of the 21 selected herbal medicines for 48 h, the proliferative activity, the effects on androgen receptor (AR) and prostate specific antigen (PSA) were determined. The anti-tumor effects of the 21 herbs on PCa growth were also investigated on a subcutaneous mouse model of PCa.
The results showed that Epimedii Folium (EF) and Codonopsis Radix (CNR) could significantly increase the cell viability in LNCaP cells (p < 0.05 for both) and 22Rv1 cells (p < 0.05 for both), protein expressions of AR in LNCaP cells (p < 0.05 for both) and 22Rv1 cells (p < 0.05 for both), and PSA (p < 0.05 for both) in LNCaP cells. EF, CNR, and Cistanches Herba (CCH) markedly accentuated the tumor growth (p < 0.05 for three drugs) and AR expression (p < 0.05 for three herbs) in tumor tissues. On the other hand, treatment with Astragali Radix (AGR), Chuanxiong Rhizoma (CXR) and Bruceae Fructus (BF) significantly inhibited the cell viability in LNCaP cells (p < 0.05, p < 0.05 and p < 0.001, respectively) and in 22Rv1 cells (p < 0.05, p < 0.05 and p < 0.001, respectively), and the protein expression of AR in LNCaP cells (p < 0.05 for three herbs) and 22Rv1 cells (p < 0.05, p < 0.05 and p < 0.001, respectively), and the protein expression of PSA (p < 0.05 for three herbs) in LNCaP cells, as well as tumor growth (p < 0.05 for three herbs) and the AR expression (p < 0.05 for AGR and CXR, p < 0.001 for BF) in tumor tissues.
Our results revealed that AGR, CXR and BF suppressed the PCa development via inhibition of AR expression, while EF, CNR and CCH promoted the development and progression of PCa via enhancement of AR expression. The results strongly suggest that caution should be exercised when using androgenic Chinese herbal medicines in PCa patients.
[Display omitted]]]></description><subject>Androgen receptor</subject><subject>Androgen Receptor Antagonists - pharmacology</subject><subject>Androgen Receptor Antagonists - toxicity</subject><subject>Androgens - pharmacology</subject><subject>Androgens - toxicity</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - toxicity</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chinese herbal medicine</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - toxicity</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>Mice, Nude</subject><subject>Phytoandrogens</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Receptors, Androgen - drug effects</subject><subject>Receptors, Androgen - genetics</subject><subject>Receptors, Androgen - metabolism</subject><subject>Signal Transduction</subject><subject>Tumor Burden - drug effects</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenograph</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1OwzAQhS0EoqVwADbIF0ix4zhOxApV5UeqxAbWluNMGkdtHNlugUtwZhwFWLIazei9p3kfQteULCmh-W237GBYpiSNO2WEFydoTguRJoILdormhIkiKURGZ-jC-44QImhGztGMpTzlJC_m6Gt9VLuDCsb22DY4tIChaUAHP66qr53dQm80XrWmBw-4BVepHd5DbfR4wdH4K8MONAzBOj-ecDjsrcNbZ99Di02P4WMAZ_bQhxgwOOuDCoC16jU4vLc17PwlOmvUzsPVz1ygt4f16-op2bw8Pq_uN4lmnIWkSnOuRAmkUkCzkpQ8y7hWZa2FKNnYnlWVakhTEJ3XVVkqytOyyJs0pyz-yBaITrk6vuEdNHKInyn3KSmRI1vZychWjmzlxDZ6bibPcKhi_T_HL8wouJsEsQgcDTjptYHYrjYRTJC1Nf_EfwNpJY0I</recordid><startdate>20201005</startdate><enddate>20201005</enddate><creator>Zhang, Zhen-Biao</creator><creator>Ip, Siu-Po</creator><creator>Cho, William Chi</creator><creator>Hu, Zhen</creator><creator>Huang, Yan-Feng</creator><creator>Luo, Dan-Dan</creator><creator>Xian, Yan-Fang</creator><creator>Lin, Zhi-Xiu</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201005</creationdate><title>Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models</title><author>Zhang, Zhen-Biao ; Ip, Siu-Po ; Cho, William Chi ; Hu, Zhen ; Huang, Yan-Feng ; Luo, Dan-Dan ; Xian, Yan-Fang ; Lin, Zhi-Xiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Androgen receptor</topic><topic>Androgen Receptor Antagonists - pharmacology</topic><topic>Androgen Receptor Antagonists - toxicity</topic><topic>Androgens - pharmacology</topic><topic>Androgens - toxicity</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - toxicity</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chinese herbal medicine</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - toxicity</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>Mice, Nude</topic><topic>Phytoandrogens</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Receptors, Androgen - drug effects</topic><topic>Receptors, Androgen - genetics</topic><topic>Receptors, Androgen - metabolism</topic><topic>Signal Transduction</topic><topic>Tumor Burden - drug effects</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Xenograph</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zhen-Biao</creatorcontrib><creatorcontrib>Ip, Siu-Po</creatorcontrib><creatorcontrib>Cho, William Chi</creatorcontrib><creatorcontrib>Hu, Zhen</creatorcontrib><creatorcontrib>Huang, Yan-Feng</creatorcontrib><creatorcontrib>Luo, Dan-Dan</creatorcontrib><creatorcontrib>Xian, Yan-Fang</creatorcontrib><creatorcontrib>Lin, Zhi-Xiu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhen-Biao</au><au>Ip, Siu-Po</au><au>Cho, William Chi</au><au>Hu, Zhen</au><au>Huang, Yan-Feng</au><au>Luo, Dan-Dan</au><au>Xian, Yan-Fang</au><au>Lin, Zhi-Xiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2020-10-05</date><risdate>2020</risdate><volume>260</volume><spage>113058</spage><pages>113058-</pages><artnum>113058</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract><![CDATA[Many prostate cancer (PCa) patients in Mainland China and other Asian countries often use Chinese herbal medicines as an adjuvant treatment while receiving Western medicines. However, concerns have been raised about the potential herb-drug interaction when using herbal medicines containing phytoandrogens.
This study aimed to investigate the effects of the selected 21 Chinese herbal medicines on the proliferation and tumor growth using the relevant in vitro and in vivo models of PCa.
After treatment of LNCaP and 22Rv1 cells with different concentrations of 70% ethanol extracts of the 21 selected herbal medicines for 48 h, the proliferative activity, the effects on androgen receptor (AR) and prostate specific antigen (PSA) were determined. The anti-tumor effects of the 21 herbs on PCa growth were also investigated on a subcutaneous mouse model of PCa.
The results showed that Epimedii Folium (EF) and Codonopsis Radix (CNR) could significantly increase the cell viability in LNCaP cells (p < 0.05 for both) and 22Rv1 cells (p < 0.05 for both), protein expressions of AR in LNCaP cells (p < 0.05 for both) and 22Rv1 cells (p < 0.05 for both), and PSA (p < 0.05 for both) in LNCaP cells. EF, CNR, and Cistanches Herba (CCH) markedly accentuated the tumor growth (p < 0.05 for three drugs) and AR expression (p < 0.05 for three herbs) in tumor tissues. On the other hand, treatment with Astragali Radix (AGR), Chuanxiong Rhizoma (CXR) and Bruceae Fructus (BF) significantly inhibited the cell viability in LNCaP cells (p < 0.05, p < 0.05 and p < 0.001, respectively) and in 22Rv1 cells (p < 0.05, p < 0.05 and p < 0.001, respectively), and the protein expression of AR in LNCaP cells (p < 0.05 for three herbs) and 22Rv1 cells (p < 0.05, p < 0.05 and p < 0.001, respectively), and the protein expression of PSA (p < 0.05 for three herbs) in LNCaP cells, as well as tumor growth (p < 0.05 for three herbs) and the AR expression (p < 0.05 for AGR and CXR, p < 0.001 for BF) in tumor tissues.
Our results revealed that AGR, CXR and BF suppressed the PCa development via inhibition of AR expression, while EF, CNR and CCH promoted the development and progression of PCa via enhancement of AR expression. The results strongly suggest that caution should be exercised when using androgenic Chinese herbal medicines in PCa patients.
[Display omitted]]]></abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32525068</pmid><doi>10.1016/j.jep.2020.113058</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2020-10, Vol.260, p.113058, Article 113058 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_crossref_primary_10_1016_j_jep_2020_113058 |
| source | Elsevier |
| subjects | Androgen receptor Androgen Receptor Antagonists - pharmacology Androgen Receptor Antagonists - toxicity Androgens - pharmacology Androgens - toxicity Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - toxicity Cell Line, Tumor Cell Proliferation - drug effects Chinese herbal medicine Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - toxicity Gene Expression Regulation, Neoplastic Humans Male Mice, Nude Phytoandrogens Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - drug effects Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction Tumor Burden - drug effects Xenograft Model Antitumor Assays Xenograph |
| title | Evaluation of the effects of androgenic Chinese herbal medicines on androgen receptors and tumor growth in experimental prostate cancer models |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T23%3A12%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20effects%20of%20androgenic%20Chinese%20herbal%20medicines%20on%20androgen%20receptors%20and%20tumor%20growth%20in%20experimental%20prostate%20cancer%20models&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Zhang,%20Zhen-Biao&rft.date=2020-10-05&rft.volume=260&rft.spage=113058&rft.pages=113058-&rft.artnum=113058&rft.issn=0378-8741&rft.eissn=1872-7573&rft_id=info:doi/10.1016/j.jep.2020.113058&rft_dat=%3Celsevier_cross%3ES0378874120303056%3C/elsevier_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c353t-b265a79e0bae149095445ca9dc779375733bbaf0f80c6db99a152986f2613ece3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/32525068&rfr_iscdi=true |