Recent progress in transition-metal-catalyzed trifluoromethylation of olefins using electrophilic CF3 reagents

Recent developments of trifluoromethylation of olefins effected by a combination of transition metal catalysis and electrophilic trifluoromethylating reagents such as Umemoto's and Togni's reagents are reviewed. •Trifluoromethylation of olefins.•Transition metal catalysis.•Electrophilic tr...

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Bibliographic Details
Published in:Journal of fluorine chemistry 2014-11, Vol.167, p.30-36
Main Authors: Koike, Takashi, Akita, Munetaka
Format: Article
Language:English
Subjects:
Alkene difunctionlalization
Electrophilic CF3 reagent
Photocatalysis
Step economy
Transition metal catalyst
Trifluoromethylation
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Summary:Recent developments of trifluoromethylation of olefins effected by a combination of transition metal catalysis and electrophilic trifluoromethylating reagents such as Umemoto's and Togni's reagents are reviewed. •Trifluoromethylation of olefins.•Transition metal catalysis.•Electrophilic trifluoromethylating reagents.•Umemoto's and Togni's reagents.•C(sp3)CF3 bond formation. For the past few years, transition-metal-catalyzed trifluoromethylation of olefins has been rapidly developing and has provided various types of organofluorine compounds containing a C(sp3)CF3 bond. In this review, we will concisely summarize recent development of trifluoromethylation of CC bonds effected by a combination of transition metal catalysis and electrophilic trifluoromethylating reagents, such as Umemoto's and Togni's reagents.
ISSN:0022-1139
1873-3328
DOI:10.1016/j.jfluchem.2014.06.025