Recent advances in fluorine chemistry using flow technology

•This review summarized fluorine chemistry with a flow reactor.•We categorized organometallic reactions, electrochemistry, photochemistry, gas-liquid reactions, heterogeneous reactions and 18F-fluorination.•An efficient strategy for using flow systems to access complex fluorine-containing molecules....

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Bibliographic Details
Published in:Journal of fluorine chemistry 2024-10, Vol.279, p.110349, Article 110349
Main Authors: Muta, Kensuke, Soutome, Hiroki, Nagaki, Aiichiro
Format: Article
Language:English
Subjects:
difluoromethylationFlow chemistry
Electrochemistry
Flash chemistry
Flow microreactor
Fluorination
Fluorine chemistry
Photochemistry
Trifluoromethylation
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Summary:•This review summarized fluorine chemistry with a flow reactor.•We categorized organometallic reactions, electrochemistry, photochemistry, gas-liquid reactions, heterogeneous reactions and 18F-fluorination.•An efficient strategy for using flow systems to access complex fluorine-containing molecules. Organofluorine compounds have proven to play an important role in pharmaceutical, agrochemical, and functional materials owing to their unique properties. However, the synthesis of these compounds is often challenging due to the difficulties in handling fluorinating agents and controlling their reactivity precisely. Recently, flow microreactor systems have attracted significant attention from chemists as a highly efficient synthetic methodology. In this review, we summarize recent advances in fluorine chemistry facilitated by continuous flow technology, highlighting its advantages and potential applications in streamlined synthesis of organofluorine compounds. [Display omitted]
ISSN:0022-1139
DOI:10.1016/j.jfluchem.2024.110349