Microencapsulation of hesperidin in polyelectrolyte complex microbeads: Physico-chemical evaluation and release behavior

The aim of the study was to develop and characterize alginate microparticles coated with polyelectrolytes and containing hesperidin – a natural bioflavonoid of great nutritional potential. Hesperidin's solubility is moderate, thus it was essential to develop a stable carrier which enables its t...

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Bibliographic Details
Published in:Journal of food engineering 2017-12, Vol.214, p.104-116
Main Authors: Tsirigotis-Maniecka, Marta, Lamch, Łukasz, Chojnacka, Ida, Gancarz, Roman, Wilk, Kazimiera A.
Format: Article
Language:English
Subjects:
Bioflavonoid
External gelation
Polyelectrolyte shell
Release characteristics
Sodium alginate
Stability studies
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Summary:The aim of the study was to develop and characterize alginate microparticles coated with polyelectrolytes and containing hesperidin – a natural bioflavonoid of great nutritional potential. Hesperidin's solubility is moderate, thus it was essential to develop a stable carrier which enables its targeted delivery to the intestine. The cargo was entrapped in the alginate (ALG) hydrogel matrix by means of the extrusion/external gelation technique. To achieve customized functional properties of microbeads, biopolymers (chitosan, gelatin) and synthetic polymers (PAH/PSS pair) were deposited on the ALG cores. The fabricated microparticles successfully encapsulated hesperidin (>87%) and were compared in terms of moisture content, surface morphology and particle size (SEM). FTIR spectroscopy confirmed the formation of polyelectrolyte complexes and the microsystems were further characterized with DSC. The swelling and release behaviors were studied in detail, including in vitro release experiments. The results obtained indicate that the fabricated microcapsules revealed the desired pH-dependent release ability. •Hesperidin (HESP) was effectively loaded (>87%) into alginate microparticles (MPs).•Chitosan, gelatin or PAH/PSS pair were deposited on the alginate matrix.•MPs efficiently protected HESP and revealed the pH-responsive release ability.•Chitosan and gelatin coatings provided the most appropriate MPs in terms of stability and controlled release abilities.•The fabricated MPs may be considered as carriers improving the oral bioavailability of HESP.
ISSN:0260-8774
1873-5770
DOI:10.1016/j.jfoodeng.2017.06.015