Effect of scaling and root planing with and without minocycline hydrochloride microspheres on serum biomarkers and acute phase reactants

• Published in: JADA foundational science 2024, Vol.3, p.100040, Article 100040
• Main Authors: Arnett, Michelle C., Costalonga, Massimo, Chanthavisouk, Phonsuda, Evans, Michael D., Paulson, Danna R.
• Format: Article
• Language: English
• Subjects: minocycline hydrochloride microspheres; Periodontitis; scaling and root planing
• ISSN: 2772-414X; 2772-414X
• DOI: 10.1016/j.jfscie.2024.100040

This study tests the effects of scaling and root planing (SRP) vs SRP with minocycline hydrochloride microspheres (MMs) (SRP with MM) on serum biomarkers interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and matrix metalloproteinase-8 and acute phase reactants hemoglobin A1c (HbA1c), high-sensitivity C-reactive proteins and haptoglobin (Hp) in patients with stage II-IV grade B periodontitis. Seventy participants were randomized to receive SRP (n = 35) or SRP+MM (n = 35). Serum was collected at baseline (before SRP), 1-month reevaluation visit, and 3- and 6-month periodontal maintenance visits. MMs were delivered to pockets 5 mm or larger immediately after SRP and immediately after the 3-month periodontal maintenance visit. Serum for acute phase reactants only was collected at the 9- and 12-month posttreatment follow-up. All outcomes were summarized using estimated marginal means back-transformed to the original response scale with 95% CIs. At 6 months, no statistical significance was yielded in either group for IL-6 (P = .91), tumor necrosis factor-α (P = .34), or matrix metalloproteinase-8 (P = .34). IL-1β (P = .06) was slightly higher in the SRP-alone group, suggesting a clinical impact with the addition of MM. Acute phase reactants were not statistically significant for high-sensitivity C-reactive proteins (P = .59), HbA1c (P = .46), or haptoglobin (P = .22) for either group. These outcomes continued at the 9- and 12-month posttreatment follow-up. SRP alone and SRP+MM minimally reduced levels of cytokine biomarkers and acute phase reactants in self-reported systemically healthy patients with advanced stages of periodontitis. Thresholds for resolution of local clinical inflammation may not have been achieved in this study to result in a reduction of systemic inflammation. [Display omitted]