Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer

AbstractBackgroundTreatment options for older patients with malignancies remain suboptimal. An accurate prognostic stratification could inform treatment decisions, which can potentially improve patient outcomes. Here, we sought to investigate whether the neutrophil-to-lymphocyte ratio (NLR) may have...

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Published in:Journal of geriatric oncology 2019-09, Vol.10 (5), p.757-762
Main Authors: Chen, Kuan-Hung, Tsang, Ngan-Ming, Chou, Wen-Chi, Tai, Shiao Fwu, Liu, Shu-Chen, Lei, Kin-Fong, Chang, Kai-Ping, Chuang, Wen-Ching, Pai, Ping-Ching
Format: Article
Language:English
Subjects:
Age
Cancer
Hematology, Oncology, and Palliative Medicine
Internal Medicine
Metastasis
Neutrophil-to-lymphocyte ratio
Prognosis
Systemic therapy
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Summary:AbstractBackgroundTreatment options for older patients with malignancies remain suboptimal. An accurate prognostic stratification could inform treatment decisions, which can potentially improve patient outcomes. Here, we sought to investigate whether the neutrophil-to-lymphocyte ratio (NLR) may have prognostic significance in patients with metastatic malignant tumors, with a special focus on older individuals. MethodsWe retrospectively reviewed the clinical records of 3981 patients with histology-proven metastatic cancer who underwent radiotherapy between 2000 and 2013. The pretreatment NLR was determined within 7 days before treatment initiation. Patients aged ≥65 years were considered as older. We analyzed the prognostic significance of NLR for overall survival (OS) across all age groups. ResultsCompared with their younger counterparts, older patients showed a higher NLR ( P 
ISSN:1879-4068
1879-4076
DOI:10.1016/j.jgo.2019.04.015