Experimental and modeling study on removal of pharmaceutically active compounds in rotating biological contactors

The aim of this work was to study the biological removal of pharmaceutical compounds in rotating biological contactors (RBCs) under continuous operation. A two-stage RBC was used, providing a total surface area of 1.41 m(2). Four pharmaceuticals of different therapeutic classes; caffeine, sulfametho...

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Bibliographic Details
Published in:Journal of hazardous materials 2014-06, Vol.274, p.473-482
Main Authors: VASILIADOU, I. A, MOLINA, R, MARTINEZ, F, MELERO, J. A
Format: Article
Language:English
Subjects:
Adsorption
Applied sciences
Biofilms
Bioreactors
Caffeine - metabolism
Carbamazepine - metabolism
Exact sciences and technology
Models, Theoretical
Pharmaceutical Preparations - metabolism
Pollution
Ranitidine - metabolism
Sulfamethoxazole - metabolism
Waste Disposal, Fluid - instrumentation
Water Pollutants, Chemical - metabolism
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Summary:The aim of this work was to study the biological removal of pharmaceutical compounds in rotating biological contactors (RBCs) under continuous operation. A two-stage RBC was used, providing a total surface area of 1.41 m(2). Four pharmaceuticals of different therapeutic classes; caffeine, sulfamethoxazole, ranitidine and carbamazepine, were studied. Six experimental scenarios were applied to the RBC-system by varying substrates' loadings (12-54 gCOD/d), volumetric flow rate (2-5L/d), and pharmaceuticals' concentration (20-50 μg/L). The different conditions resulted to different solid retention times (SRT: 7-21 d) in each scenario. The increase of SRT due to variations of the operating conditions seemed to have a positive effect on pharmaceuticals' removal. Likewise, a negative correlation was observed between substrates' loading and pharmaceuticals' removal. An increase of initial pharmaceuticals' concentration resulted to decrease of SRT and pharmaceuticals' removal, suggesting a toxic effect to the biofilm. The maximum removals achieved were greater than 85% for all pharmaceuticals. Finally, a mathematical model which includes biofilm growth, substrates' utilization and pharmaceuticals' elimination was developed. The model predicts the contribution of sorption and biodegradation on pharmaceuticals' elimination taking into account the diffusion of pharmaceuticals inside biofilm.
ISSN:0304-3894
1873-3336
DOI:10.1016/j.jhazmat.2014.04.034