Chitosan oligosaccharide alleviates and removes the toxicological effects of organophosphorus pesticide chlorpyrifos residues

The abuse of chlorpyrifos (CHP), a commonly used organophosphorus pesticide, has caused many environmental pollution problems, especially its toxicological effects on non-target organisms. First, CHP enriched on the surface of plants enters ecosystem circulation along the food chain. Second, direct...

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Bibliographic Details
Published in:Journal of hazardous materials 2023-03, Vol.446, p.130669, Article 130669
Main Authors: Fu, Huiyang, Liu, Haozhen, Ge, Yao, Chen, Yinfeng, Tan, Peng, Bai, Jun, Dai, Zhaolai, Yang, Ying, Wu, Zhenlong
Format: Article
Language:English
Subjects:
Animals
Chitosan - pharmacology
Chlorpyrifos
Chlorpyrifos - analysis
Chlorpyrifos - toxicity
Ecosystem
Environmental contaminant
Oligosaccharides - pharmacology
Organophosphorus Compounds
Organophosphorus pesticides
Pesticide Residues - analysis
Pesticides
Rats
Remove
Toxicological effects
Water
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Summary:The abuse of chlorpyrifos (CHP), a commonly used organophosphorus pesticide, has caused many environmental pollution problems, especially its toxicological effects on non-target organisms. First, CHP enriched on the surface of plants enters ecosystem circulation along the food chain. Second, direct inflow of CHP into the water environment under the action of rainwater runoff inevitably causes toxicity to non-target organisms. Therefore, we used rats as a model to establish a CHP exposure toxicity model and studied the effects of CHP in rats. In addition, to alleviate and remove the injuries caused by residual chlorpyrifos in vivo, we explored the alleviation effect of chitosan oligosaccharide (COS) on CHP toxicity in rats by exploiting its high water solubility and natural biological activity. The results showed that CHP can induce the toxicological effects of intestinal antioxidant changes, inflammation, apoptosis, intestinal barrier damage, and metabolic dysfunction in rats, and COS has excellent removal and mitigation effects on the toxic damage caused by residual CHP in the environment. In summary, COS showed significant biological effects in removing and mitigating blood biochemistry, antioxidants, inflammation, apoptosis, gut barrier structure, and metabolic function changes induced by residual CHP in the environment. [Display omitted] •Chlorpyrifos (CHP) residues caused the decrease in productive performance on rats.•The mechanism of CHP to intestinal toxicity is explored.•Chitosan oligosaccharide (COS) can alleviate the CHP-induced toxicological effects.•COS can effectively improve CHP-induced intestinal metabolic dysfunction on rats.
ISSN:0304-3894
1873-3336
DOI:10.1016/j.jhazmat.2022.130669