Correction of hyponatraemia improves cognition, quality of life, and brain oedema in cirrhosis

Background & Aims Hyponatraemia in cirrhosis is associated with impaired cognition and poor health-related quality of life (HRQOL). However, the benefit of hyponatraemia correction is unclear. The aim of this study was to evaluate the effect of tolvaptan on serum sodium (Na), cognition, HRQOL, c...

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Bibliographic Details
Published in:Journal of hepatology 2015-01, Vol.62 (1), p.75-82
Main Authors: Ahluwalia, Vishwadeep, Heuman, Douglas M, Feldman, George, Wade, James B, Thacker, Leroy R, Gavis, Edith, Gilles, HoChong, Unser, Ariel, White, Melanie B, Bajaj, Jasmohan S
Format: Article
Language:English
Subjects:
Antidiuretic Hormone Receptor Antagonists - administration & dosage
Aquaresis
Benzazepines - administration & dosage
Brain Edema - diagnosis
Brain Edema - drug therapy
Brain Edema - etiology
Caregiver burden
Cognition
Diffusion tensor imaging
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Gastroenterology and Hepatology
Hepatic encephalopathy
Humans
Hyponatremia - complications
Hyponatremia - drug therapy
Hyponatremia - metabolism
Liver Cirrhosis - complications
Magnetic Resonance Imaging
Magnetic resonance spectroscopy
Male
Middle Aged
Quality of Life
Sodium - blood
Sodium - urine
Tolvaptan
Treatment Outcome
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Summary:Background & Aims Hyponatraemia in cirrhosis is associated with impaired cognition and poor health-related quality of life (HRQOL). However, the benefit of hyponatraemia correction is unclear. The aim of this study was to evaluate the effect of tolvaptan on serum sodium (Na), cognition, HRQOL, companion burden, and brain MRI (volumetrics, spectroscopy, and diffusion tensor imaging) in cirrhotics with hyponatraemia. Methods Cirrhotics with Na
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2014.07.033