A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients

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Bibliographic Details
Published in:Journal of hepatology 2015-05, Vol.62 (5), p.1100-1111
Main Authors: Feng, Hai, Yu, Zhuo, Tian, Yuan, Lee, Ying-Ying, Li, May S, Go, Minnie Y.Y, Cheung, Yue-Sun, Lai, Paul B.S, Chan, Andrew M.L, To, Ka-Fai, Chan, Henry L.Y, Sung, Joseph J.Y, Cheng, Alfred S.L
Format: Article
Language:English
Subjects:
Androgen receptor
Animals
Carcinogenesis - genetics
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Chromatin modifications
Cyclin-Dependent Kinases - genetics
Ectopic Gene Expression
Enhancer of Zeste Homolog 2 Protein
Epigenesis, Genetic
Gastroenterology and Hepatology
Gender disparity
Gene Expression Regulation, Neoplastic
Hepatocellular carcinoma
Humans
Kinase
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Mice
MicroRNAs - genetics
Neoplasm Recurrence, Local - genetics
Polycomb Repressive Complex 2 - genetics
Signal Transduction - genetics
Survival Rate
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Description
Summary:Graphical abstract
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2014.11.040