A review on synthesis of antiviral drugs, in silico studies and their toxicity

Viruses have been around us for a long period of time; they are reported to affect humans, animals and plant at cellular level by using host's body to dwell and reproduce. The spread of HIV was reported in 1981 and created a global threat to public health. In the areas of basic virology, immuno...

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Bibliographic Details
Published in:Journal of the Indian Chemical Society 2023-03, Vol.100 (3), p.100936, Article 100936
Main Authors: Ratra, Sanchit, Pant, Bhaskaranand, Roy, Kapil, Manohar, Sunny, Kumar, Pradeep, Singh, Sangeeta, Tumba, Kaniki, Kumari, Kamlesh, Singh, Prashant
Format: Article
Language:English
Subjects:
Antiviral drugs
In silico study
Toxicity
Viruses
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Summary:Viruses have been around us for a long period of time; they are reported to affect humans, animals and plant at cellular level by using host's body to dwell and reproduce. The spread of HIV was reported in 1981 and created a global threat to public health. In the areas of basic virology, immunology and pathogenesis of HIV/AIDS, the development of antiretroviral medicines and significant progress has been made in recent years. Majority of these antiviral compounds have the potential to be used as HIV drugs, however they are frequently accompanied with some side effects. With the emergence of the COVID-19, human race is facing a new public health crisis and repurposing of antiviral drugs are being considered to block the function of Mpro of the new corona virus (SARS-CoV-2). This review covers the information related to the synthesis of various types of antiviral drugs and their toxicity. Some of these are used as repurposing drugs to cure patients suffering from other diseases/ infections. Therefore, information for in Silico studies of these antiviral drugs is incorporated. In brief, this review is focused on synthesis of different types of antiviral drugs, their repurposing role as well as toxicity. [Display omitted]
ISSN:0019-4522
DOI:10.1016/j.jics.2023.100936