Metallic nanocomposites − A prevailing tool to decipher the bacterial crosstalk

[Display omitted] Antimicrobial resistance in pathogenic bacteria poses a significant and growing threat to human health. The slow progress in developing new antimicrobial drugs has led to the need for innovative alternative solutions to combat the problem of antibiotic resistance. Quorum sensing (Q...

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Bibliographic Details
Published in:Journal of industrial and engineering chemistry (Seoul, Korea) Korea), 2024-09
Main Authors: Selvam, Suvetha, Mani, Arun Kumar
Format: Article
Language:English
Subjects:
Anti-quorum sensing
Anti-virulence
Antimicrobial resistance
Biofilm-associated infections
Metallic nanocomposites
Quorum sensing inhibitors
Therapeutic applications
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Summary:[Display omitted] Antimicrobial resistance in pathogenic bacteria poses a significant and growing threat to human health. The slow progress in developing new antimicrobial drugs has led to the need for innovative alternative solutions to combat the problem of antibiotic resistance. Quorum sensing (QS) could be a novel anti-virulent target to control virulence and biofilm development. Quorum sensing inhibitors (QSIs) have gained much attention in mitigating virulence. Targeting these systems using metal-based nanocomposites represents a new perspective for treating AMR due to their unique physicochemical and therapeutic properties. Silver, copper, zinc oxide, cerium oxide, and zirconium oxide nanoparticles have recently been studied extensively as novel anti-QS agents. This review aims to provide an overview of the recent progress in using metallic nanocomposites as a novel anti-QS agent to alleviate biofilm-associated infections.
ISSN:1226-086X
DOI:10.1016/j.jiec.2024.09.044