Water dispersible CoFe2O4 nanoparticles with improved colloidal stability for biomedical applications

Single phase cobalt ferrite (CoFe2O4, CFO) nanoparticles of a controlled size (∼6nm) exhibiting superparamagnetic properties have been synthesized by hydrothermal technique using oleic acid (OA) as surfactant. The oleic acid coated CFO nanoparticles are stable in non-polar organic media, such as hex...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2016-04, Vol.404, p.166-169
Main Authors: Munjal, Sandeep, Khare, Neeraj, Nehate, Chetan, Koul, Veena
Format: Article
Language:English
Subjects:
Biomedical applications
CoFe2O4
Ligand exchange
Nanoparticles
Superparamagnetism
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Summary:Single phase cobalt ferrite (CoFe2O4, CFO) nanoparticles of a controlled size (∼6nm) exhibiting superparamagnetic properties have been synthesized by hydrothermal technique using oleic acid (OA) as surfactant. The oleic acid coated CFO nanoparticles are stable in non-polar organic media, such as hexane but are not well dispersible in water. The surface of these nanoparticles has been further modified by citric acid using ligand exchange process, which makes CFO nanoparticles more stable colloidal solution in water. Citric acid coated CFO nanoparticles exhibits high dispersibility in water, high zeta potential, very low coercivity and moderate saturation magnetization. Biocompatibility of these CFO nanoparticles is demonstrated through cytotoxicity test in L929 cell line. •Synthesis of uniform size (~6nm) CoFe2O4 (CFO) magnetic nano-particles, with a narrow size distribution using hydrothermal techniques with oleic acid as surfactant and convert the CFO nano-particles highly dispersible in water by modifying the surface of nanoparticles through ligand exchange process.•The bio-compatibility of these highly water dispersal citric acid coated CoFe2O4 nanoparticles was demonstrated with mouse fibroblast L929 cells lines, using a MTT cytotoxicity assay.•The surface of these oleic acid coated nanoparticles was modified with citric acid using ligand exchange method, that makes these nanoparticles water highly dispersible.•The biocompatibility of citric acid coated CoFe2O4 nanoparticles was demonstrated with mouse fibroblast L929 cells lines, using a MTT cytotoxicity assay.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2015.12.017