Multifunctional metal-polyphenol nanocomposite for melanoma targeted photo/chemodynamic synergistic therapy

• Published in: Journal of materials science & technology 2023-07, Vol.152, p.159-168
• Main Authors: Chuan, Di, Hou, Huan, Wang, Yuelong, Mu, Min, Li, Jinglun, Ren, Yangmei, Zhao, Na, Han, Bo, Chen, Haifeng, Guo, Gang
• Format: Article
• Language: English
• Subjects: Chemodynamic therapy; Fenton reaction; Metal-polyphenol network; Photodynamic therapy
• ISSN: 1005-0302; 1941-1162
• DOI: 10.1016/j.jmst.2022.12.039

•A Ce6 loading metal-polyphenol nanocomposite (Ce6@HSF NPs) was designed for melanoma synergistic therapy.•Ce6@HSF NPs could be used as a Fenton reagent to induce the ·OH production.•Ce6@HSF NPs can combine photodynamic therapy and chemodynamic therapy.•Ce6@HSF NPs can enhance the photodynamic therapy effect of Ce6. Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H2O2 in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment. Herein, a metal-polyphenol nanocomposite was deposited with gallic acid grafted hyaluronic acid and Fe3+ to contrast a Ce6 nano-delivery system (Ce6@HSF NPs) for melanoma synergistic therapy. Ce6@HSF NPs could be used as a Fenton reagent to induce the ·OH production and enhance the PDT effect of Ce6 to a certain extent. After 4 h of cellular uptake, the fluorescence intensity of Ce6 in the Ce6@HSF NPs group was higher than 3 times that in the Ce6 group. The intracellular ROS generation level of the Ce6@HSF NPs (L) group combining CDT and PDT was higher than that of the Ce6 group and Ce6@HSF NPs group. In vitro and in vivo anti-melanoma studies show that Ce6@HSF NPs (L) group exhibited better anti-melanoma than other groups. Together, Ce6@HSF NPs provide a promising synergistic treatment potential for melanoma. [Display omitted]