Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques

Abstract Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation m...

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Bibliographic Details
Published in:Journal of neuroimmunology 2013-08, Vol.261 (1), p.60-66
Main Authors: Barcia, Carlos, Ros, Carmen María, Ros-Bernal, Francisco, Gómez, Aurora, Annese, Valentina, Carrillo-de Sauvage, María Angeles, Yuste, José Enrique, Campuzano, Carmen María, de Pablos, Vicente, Fernández-Villalba, Emiliano, Herrero, María Trinidad
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cell polarity
Dopaminergic degeneration
Female
Inflammation
Macaca fascicularis
Male
Microglia - immunology
Microglia - metabolism
Microglia - pathology
Microglial motility
MPTP
Neurology
Parkinson Disease - immunology
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson's disease
Phagocytes - immunology
Phagocytes - metabolism
Phagocytes - pathology
Phagocytosis - immunology
Substantia Nigra - immunology
Substantia Nigra - metabolism
Substantia Nigra - pathology
Time Factors
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Summary:Abstract Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2013.05.001