Acid catalysed synthesis of bioactive glass by evaporation induced self assembly method

• Published in: Journal of non-crystalline solids 2018-01, Vol.479, p.1-8
• Main Authors: Shah, Asma Tufail, Ain, Quratul, Chaudhry, Aqif Anwar, Ahmad, Sana, Zarif, Faiza, Siddiqi, Saadat Anwar, Qasim, Saad bin, Görke, Oliver, Khan, Abdul Samad, Rehman, Ihtesham ur
• Format: Article
• Language: English
• Subjects: Bioactive glass; Biocompatibility; Biomedical application; Glass ceramics; Sol-gel process
• ISSN: 0022-3093; 1873-4812
• DOI: 10.1016/j.jnoncrysol.2017.09.041

Bioactive glass (BG) with uniform spherical morphology was prepared by EISA (Evaporation Induced Self Assembly) process using non-ionic Pluronic F127 as structure directing agent and phosphoric acid as a source of P2O5 and compared with conventional precursor triethyl phosphate (TEP). EISA method proceeds through ionic interaction mechanism by protonation of surfactant and silicic species. H3PO4 provides H+ and PO43− ions in reaction medium which play critical role in reaction mechanism. Hydrogen ions increase the protonation of H2O and surfactant, while PO43− ions act as bridging molecule between different cations, ensuring incorporation of phosphorus in BG network. TEP participates by proton acceptance mechanism, creating competitive environment. Thus H3PO4 facilitates the formation of BG in presence of non-ionic surfactant Pluronic F127. The prepared glasses were characterized by FTIR, SEM-EDX, TGA-DSC and BET surface analyzer. Uniform spherical morphology, improved dispersity, relatively large surface area and better cells focal attachment were observed for BG-H3PO4, prepared by using H3PO4. SiO2–CaO–P2O5 mol% composition of BG-H3PO4 was (66:24:10) close to the theoretical value (65:25:10), while for BG-TEP the actual ratio was (77:20.5:2.5). The surface reactivity, studied by soaking in simulated body fluid, showed rapid growth of hydroxyapatite with Ca/P ratio 1.67 on BG-H3PO4. The proliferation of MC3T3 cells on BG-H3PO4 was remarkably improved as compared to conventional BG. Thus BG-H3PO4 can be considered for biomedical applications in future especially for drug loading and composite application where homogeneous and uniform structure are of utmost importance. •H3PO4 is an efficient source of P2O5 for bioactive glass (BG).•It catalyzes the sol gel process by providing H+ and PO43− ions.•It produces BG of spherical morphology, better dispersity and large surface area.•H3PO4 leads to rapid growth of hydroxyapatite with Ca/P ratio 1.67.•The source changes the cytotoxicity/biocompatibility of bioactive glass.