Synthesis and characterization of mesoporous ZnO/SBA-16 nanocomposite: Its efficiency as drug delivery system

•We report the synthesis of new mesoporous ZnO/SBA-16 nanocarriers for temozolomide drug.•Encapsulation loading efficiency % were surveyed by design of experiment software and the features of release were measured.•Highest percentage of absorption can be achieved by optimization of the effective fac...

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Bibliographic Details
Published in:Journal of non-crystalline solids 2022-09, Vol.591, p.121512, Article 121512
Main Authors: Fekri, Mohammad Hossein, Soleymani, Samaneh, Mehr, Maryam Razavi, Akbari-adergani, Behrouz
Format: Article
Language:English
Subjects:
Design of experiment
Drug release
Encapsulation efficiency
SBA-16
ZnO nanoparticles
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Summary:•We report the synthesis of new mesoporous ZnO/SBA-16 nanocarriers for temozolomide drug.•Encapsulation loading efficiency % were surveyed by design of experiment software and the features of release were measured.•Highest percentage of absorption can be achieved by optimization of the effective factors on loading drug. A modified straightforward process is introduced to synthesize zinc oxide nanoparticles into the pores of a mesoporous silica SBA-16 as host. The mesoporous structure and the ZnO nanoparticles were analyzed by infrared spectroscopy, X-ray diffractometry, scanning electron microscopy, transmission electron microscopy, and nitrogen sorption analysis. The loading and release of temozolomide from ZnO/SBA-16 nanocomposite were studied. Encapsulation loading efficiency % was surveyed by design of experiment software and the features of release were measured. Results show the highest percentage of adsorption can be achieved by optimization of the effective factors on loading drug. Moreover, SBA-16 loaded with nano ZnO exhibited controlled drug release. [Display omitted]
ISSN:0022-3093
1873-4812
DOI:10.1016/j.jnoncrysol.2022.121512