Expression of hypoxia inducible factor-1 α in tumors of patients with glioblastoma multiforme and transitional meningioma

Abstract Hypoxia-inducible factor-1 α (HIF-1 α ) is the major transcriptional factor involved in the adaptive response to hypoxia. The aim of this study was to assess HIF-1 α in 22 patients with transitional meningioma (TM) and 26 patients with glioblastoma multiforme (GBM). HIF-1 α was assessed usi...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2008-09, Vol.15 (9), p.1036-1042
Main Authors: Kaynar, Mehmet Yasar, Sanus, Galip Zihni, Hnimoglu, Hakan, Kacira, Tibet, Kemerdere, Rahsan, Atukeren, Pinar, Gumustas, Koray, Canbaz, Bulent, Tanriverdi, Taner
Format: Article
Language:English
Subjects:
Brain tumors
Glioblastoma multiforme
HIF-1
Hypoxia
Meningioma
Neurology
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Summary:Abstract Hypoxia-inducible factor-1 α (HIF-1 α ) is the major transcriptional factor involved in the adaptive response to hypoxia. The aim of this study was to assess HIF-1 α in 22 patients with transitional meningioma (TM) and 26 patients with glioblastoma multiforme (GBM). HIF-1 α was assessed using a commercially available enzyme-linked immunosorbent assay-based HIF-1 transcription factor assay. Levels of HIF-1 α in TM and GBM were measured using optical density at 450 nm, and median values were found to be 0.35 for TM and 0.37 OD for GBM, respectively. There was no statistically significant difference between the two types of tumor ( p = 0.264). These findings indicate that HIF-1 α is elevated in both TM and GBM, suggesting that although hypoxia is one of the most important and powerful stimuli for HIF-1 α elevation and consequently angiogenesis, other mechanisms may play roles in HIF-1 α stimulation in benign brain tumors such as TM.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2007.07.080