Is carbamazepine a human teratogen?

Highlights • Carbamazepine in monotherapy is associated with a two-fold increase of foetal malformations. • Carbamazepine is not an adequate comparator for the malformation risk in pregnancy. • Levetiracetam related risks are comparable to those of untreated women in pregnancy.

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Bibliographic Details
Published in:Journal of clinical neuroscience 2016-01, Vol.23, p.34-37
Main Authors: Vajda, F.J.E, O’Brien, T.J, Graham, J, Lander, C.M, Eadie, M.J
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - epidemiology
Adult
Anticonvulsants - adverse effects
Australia
Carbamazepine - adverse effects
Epilepsy - drug therapy
Female
Fetus - drug effects
Humans
Neurology
Piracetam - adverse effects
Piracetam - analogs & derivatives
Pregnancy
Pregnancy Complications - drug therapy
Registries
Risk
Teratogens
Valproic Acid - adverse effects
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Description
Summary:Highlights • Carbamazepine in monotherapy is associated with a two-fold increase of foetal malformations. • Carbamazepine is not an adequate comparator for the malformation risk in pregnancy. • Levetiracetam related risks are comparable to those of untreated women in pregnancy.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2015.07.011