Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells

Ursolic acid (UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer (BC) and colorectal ca...

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Bibliographic Details
Published in:Journal of integrative medicine 2019-05, Vol.17 (3), p.155-160
Main Authors: Chan, Eric Wei Chiang, Soon, Chu Yong, Tan, Joash Ban Lee, Wong, Siu Kuin, Hui, Yew Woh
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Breast Neoplasms - drug therapy
Breast Neoplasms - physiopathology
Cell Proliferation - drug effects
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - physiopathology
Cytotoxic
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - chemistry
Female
Humans
Male
Molecular targets
Signaling pathways
Triterpenes - administration & dosage
Triterpenes - adverse effects
Triterpenes - chemistry
Ursolic Acid
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Summary:Ursolic acid (UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer (BC) and colorectal cancer (CRC) that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways. There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives. Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed.
ISSN:2095-4964
DOI:10.1016/j.joim.2019.03.003