Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes

• Published in: Journal of organometallic chemistry 2021-12, Vol.954-955, p.122082, Article 122082
• Main Authors: Şahin, Neslihan, Üstün, Elvan, Tutar, Uğur, Çelik, Cem, Gürbüz, Nevin, Özdemir, İsmail
• Format: Article
• Language: English
• Subjects: Antimicrobial activity; Benzimidazolium salt; Biofilm activity; Molecular docking; N-heterocyclic carbene
• ISSN: 0022-328X; 1872-8561
• DOI: 10.1016/j.jorganchem.2021.122082

•Synthesis and characterization of new benzimidazolium molecules and their silver complexes•Antimicrobial and antibiofilm activities of NHC precursors and their Ag complexes•Molecular docking analysis against three target molecules of structural optimized molecules. In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were characterized by elemental analysis, FT-IR, LC-MS, 1H NMR, and 13C{1H} NMR spectroscopy. These new N-heterocyclic carbene precursors and Ag(I)-NHC complexes were evaluated for their antibacterial, antifungal, and antibiofilm activities. The biological activities of synthesized products were compared with standard drugs. All compounds have moderate antibacterial and antibiofilm activities. In particular, while compound 2a was found to be the best inhibitor of E. coli biofilms, while compound 2d inhibited C. albicans biofilm at the highest rate. All the compounds were also analyzed by molecular docking methods with the certain target molecules. [Display omitted]