Recent developments in metal-catalysed transamidation of quiescent amides

•Transamidation is the key reaction in organic synthesis.•Metal-Catalysed transamidation of unactivated amides.•Various transition and non-transition metals have been used as catalyst. Amides played a vital role in the development of organic synthesis in recent years. These structural motifs are fou...

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Bibliographic Details
Published in:Journal of organometallic chemistry 2024-09, Vol.1018, p.123290, Article 123290
Main Authors: Sakthivel, Kokila, S, Shakir Ahmed, S, Niharan, Singh, Fateh V.
Format: Article
Language:English
Subjects:
Amides
Amines
Catalyst
Lanthanides
Transamidation
Transition metals
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Summary:•Transamidation is the key reaction in organic synthesis.•Metal-Catalysed transamidation of unactivated amides.•Various transition and non-transition metals have been used as catalyst. Amides played a vital role in the development of organic synthesis in recent years. These structural motifs are found in several biologically important synthetic and naturally occurring compounds. Developing efficient methods for their synthesis is crucial for drug discovery. Transamidation is a prominent tool in organic and medicinal chemistry, enabling the replacement of the amine group in an existing amide with new functionalised amines. Additionally, Transamidation process is used significantly in the total synthesis of few naturally occurring compounds. Transamidation reaction has been achieved significantly by using metal catalysis but there are several metal-free approaches have been employed to achieve the same reaction. This review focuses on recent literature concerning metal-catalysed transamidation reactions, highlighting the use of alkaline earth metals, transition metals, lanthanides, actinides, alkali metal salts or complexes, and metalloids. Both catalytic and stoichiometric quantities of catalysts are discussed for their roles in enhancing reaction efficiency. [Display omitted]
ISSN:0022-328X
DOI:10.1016/j.jorganchem.2024.123290