Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee

The efficacy and safety of a once-daily extended-release formulation of tramadol hydrochloride (tramadol ER) was evaluated in patients with moderate to severe chronic pain of osteoarthritis (OA). This was a randomized, double-blind, placebo-controlled, parallel-group, 12-week study. Eligible patient...

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Bibliographic Details
Published in:Journal of pain and symptom management 2004-07, Vol.28 (1), p.59-71
Main Authors: Babul, Najib, Noveck, Robert, Chipman, Howard, Roth, Sanford H, Gana, Theophilus, Albert, Kenneth
Format: Article
Language:English
Subjects:
Aged
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Biological and medical sciences
Chronic Disease
chronic pain
Delayed-Action Preparations
extended-release
Female
Humans
Male
Medical sciences
Middle Aged
once-daily administration
osteoarthritis
Osteoarthritis, Knee - complications
Pain - drug therapy
Pharmacology. Drug treatments
physical function
randomized clinical trial
sleep
Tramadol
Tramadol - administration & dosage
Tramadol - adverse effects
Treatment Outcome
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Summary:The efficacy and safety of a once-daily extended-release formulation of tramadol hydrochloride (tramadol ER) was evaluated in patients with moderate to severe chronic pain of osteoarthritis (OA). This was a randomized, double-blind, placebo-controlled, parallel-group, 12-week study. Eligible patients with radiographically confirmed OA of the knee meeting the American College of Rheumatology diagnostic criteria, defined by knee pain and presence of osteophytes, plus at least age >50 years, morning stiffness
ISSN:0885-3924
1873-6513
DOI:10.1016/j.jpainsymman.2003.11.006