Time-dependent conversion of benzyl alcohol to benzaldehyde and benzoic acid in aqueous solutions

The oxidative reaction: benzyl alcohol–benzaldehyde–benzoic acid was investigated in time in aqueous solutions of benzyl alcohol widely used as a preservative in medicine and cosmetology. The solutions of benzyl alcohol were stored at concentrations from 0.005 to 2.09 mg/ml for a long time under dif...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2006-06, Vol.41 (4), p.1380-1385
Main Authors: Sudareva, N.N., Chubarova, E.V.
Format: Article
Language:English
Subjects:
Anesthetics, Local - analysis
Anesthetics, Local - chemistry
Benzaldehyde
Benzaldehydes - analysis
Benzoic acid
Benzoic Acid - analysis
Benzyl alcohol
Benzyl Alcohol - analysis
Benzyl Alcohol - chemistry
Chromatography, Liquid
Drug Storage
Oxidation in aqueous solutions
Oxidation-Reduction
Solutions
Time Factors
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Summary:The oxidative reaction: benzyl alcohol–benzaldehyde–benzoic acid was investigated in time in aqueous solutions of benzyl alcohol widely used as a preservative in medicine and cosmetology. The solutions of benzyl alcohol were stored at concentrations from 0.005 to 2.09 mg/ml for a long time under different conditions. The presence of benzaldehyde and benzoic acid in these solutions was controlled by liquid chromatography on silica sorbent in water. The content of benzoic acid and potentially toxic benzaldehyde in solutions depending on the initial concentration of benzyl alcohol, on time, and on storage conditions was evaluated quantitatively.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2006.02.028