Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine

[Display omitted] •The small-angle X-ray scattering was applied to characterize the drug carrier system.•It was shown that the phospholipid transport nanosystem is vesicular system.•Size of vesicles was determined. Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosph...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2015-10, Vol.114, p.288-291
Main Authors: Kiselev, M.A., Zemlyanaya, E.V., Ipatova, O.M., Gruzinov, A.Yu, Ermakova, E.V., Zabelin, A.V., Zhabitskaya, E.I., Druzhilovskaya, O.S., Aksenov, V.L.
Format: Article
Language:English
Subjects:
Drug Carriers
Drug Delivery Systems
Emulsions
Glycine max - chemistry
Lipid Bilayers - chemistry
Micelles
Nanoparticles - chemistry
Phosphatidylcholines - chemistry
Scattering, Radiation
Solvents
Synchrotron
Vesicles
X-ray scattering
X-Rays
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Summary:[Display omitted] •The small-angle X-ray scattering was applied to characterize the drug carrier system.•It was shown that the phospholipid transport nanosystem is vesicular system.•Size of vesicles was determined. Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160±2Å.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2015.05.034