Determination of polycyclic aromatic hydrocarbons in lipstick by gas-chromatography coupled to mass spectrometry: A case history

•Development of an extraction protocol for the determination of PAHs in cosmetic products.•Optimization and validation of a GC/MS method for the analysis of PAHs.•Assessment of the potential risk for consumer health. A suitable extraction protocol based on an liquid-liquid extraction with hexane/dim...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2019-02, Vol.165, p.386-392
Main Authors: Roda, Gabriella, Arnoldi, Sebastiano, Casagni, Eleonora, Dei Cas, Michele, Silva, Laura, Carini, Marina
Format: Article
Language:English
Subjects:
Consumer Product Safety
Cosmetic products
Cosmetics - analysis
Cosmetics - chemistry
Cosmetics - standards
Gas Chromatography-Mass Spectrometry - methods
GC/MS
Humans
Liquid-Liquid Extraction
Polycyclic aromatic hydrocarbons (PAHs)
Polycyclic Aromatic Hydrocarbons - analysis
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Summary:•Development of an extraction protocol for the determination of PAHs in cosmetic products.•Optimization and validation of a GC/MS method for the analysis of PAHs.•Assessment of the potential risk for consumer health. A suitable extraction protocol based on an liquid-liquid extraction with hexane/dimethyl sulfoxide and a GC/MS method were developed and validated to determine the concentration of six prohibited Polycyclic Aromatic Hydrocarbons (PAHs; benzo[a]pyrene; dibenz[a,h]anthracene; benz[a]anthracene; benzo[j]fluoranthene; benzo[k]fluoranthene; chrysene) in lipsticks commissioned by a cosmetic company to a manufacturer. The lipsticks were produced in four different colors. Analyses confirmed the presence of benz[a]anthracene and chrysene only in two colors in a concentration of 9.3–9.4 ng/g. The concentration of PAHs was 250 times lower than what is considered a toxic level on the basis of what reported in the litaraure and guidances for cosmetic ingredients; therefore we could assume that the risk for consumer health was negligeble.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2018.12.029