Computational Fluid Dynamic Modeling Reveals Nonlinear Airway Stress during Trachea Development

Normative trachea dimensions and aerodynamic information during development was collected to establish clinical benchmarks and showed that airway development seems to outpace respiratory demands. Infants and toddlers' trachea exhibit higher aerodynamic stress that significantly decreases by tee...

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Bibliographic Details
Published in:The Journal of pediatrics 2021-11, Vol.238, p.324-328.e1
Main Authors: Mason, Eric C., Wu, Zhenxing, McGhee, Sam, Markley, Jennifer, Koenigs, Maria, Onwuka, Amanda, Chiang, Tendy, Zhao, Kai
Format: Article
Language:English
Subjects:
Adolescent
airflow metrics
airway modeling
Airway Resistance - physiology
Child
Child, Preschool
Cohort Studies
Computer Simulation
Female
Humans
Hydrodynamics
Infant
Male
pediatric airway physiology
Stress, Physiological - physiology
Trachea - growth & development
Trachea - physiopathology
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Summary:Normative trachea dimensions and aerodynamic information during development was collected to establish clinical benchmarks and showed that airway development seems to outpace respiratory demands. Infants and toddlers' trachea exhibit higher aerodynamic stress that significantly decreases by teenage years. This implies large airway pathology in younger children may have a more substantial clinical impact.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2021.07.038