Ginsenoside Rb1 inhibits cardiomyocyte apoptosis and rescues ischemic myocardium by targeting Caspase-3

[Display omitted] •Virtual screening was performed to predict the targets of Rb1 against MI•Proteomics, CETSA, MD simulation etc. were used to explore the targets•Rb1 does not affect the cleavage of upstream protein Caspase-9 of CASP3•Rb1 inhibits CASP3 cleavage by binding to two His121 sites in CAS...

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Published in:Journal of pharmaceutical analysis 2024-11, p.101142, Article 101142
Main Authors: Zhong, Chenhui, Ke, Liyuan, Hu, Fen, Lin, Zuan, Ye, Shuming, Zheng, Ziyao, Han, Shengnan, Lin, Zan, Zhan, Yuying, Hu, Yan, Shi, Peiying, Wen, Lei, Yao, Hong
Format: Article
Language:English
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Summary:[Display omitted] •Virtual screening was performed to predict the targets of Rb1 against MI•Proteomics, CETSA, MD simulation etc. were used to explore the targets•Rb1 does not affect the cleavage of upstream protein Caspase-9 of CASP3•Rb1 inhibits CASP3 cleavage by binding to two His121 sites in CASP3•Rb1 exerts anti-MI effect via directly targeting CASP3
ISSN:2095-1779
DOI:10.1016/j.jpha.2024.101142