A rhodol-based fluorescent probe for ratiometric sensing of hydrogen sulfide in living cells

[Display omitted] •Ratiometric fluorescent probe for detecting H2S.•NIR emission wavelength and high energy transfer efficiency.•Excellent sensitivity and selectivity.•Achieving the detection of exogenous and endogenous H2S in living cells. Hydrogen sulfide is an important signaling molecule which p...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. A, Chemistry. Chemistry., 2024-05, Vol.450, p.115450, Article 115450
Main Authors: Wei, Bing-Yu, Yan, Xiao-Meng, Yuan, Yu-Chang, Miao, Jun-Ying, Zhao, Bao-Xiang, Lin, Zhao-Min
Format: Article
Language:English
Subjects:
Cell imaging
FRET
Hydrogen sulfide
Near-infrared
Rhodol derivative
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Summary:[Display omitted] •Ratiometric fluorescent probe for detecting H2S.•NIR emission wavelength and high energy transfer efficiency.•Excellent sensitivity and selectivity.•Achieving the detection of exogenous and endogenous H2S in living cells. Hydrogen sulfide is an important signaling molecule which plays a vital role in many biological processes. In this work, a novel near-infrared FRET (fluorescence resonance energy transfer) fluorescent probe was developed based on the rhodol derivative to detect H2S. The ratio of fluorescent intensity with the concentration of H2S exhibited an excellent linear relationship when probe LT responded to H2S. Probe LT exhibited excellent selectivity, sensitivity and anti-interference. LT was applied to sense endogenous and exogenous H2S in cells with great performance. Moreover, LT had the ability to target endoplasmic reticulum (ER) in Hela cells.
ISSN:1010-6030
1873-2666
DOI:10.1016/j.jphotochem.2023.115450