The gastric fluid proteome as a potential source of gastric cancer biomarkers

Gastric cancer is a significant cause of death in many parts of the world. Although timely intervention is associated with better clinical outcome, early gastric cancer detection is frequently not possible given its asymptomatic nature. As such, sensitive and specific gastric cancer biomarkers are h...

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Bibliographic Details
Published in:Journal of proteomics 2013-09, Vol.90, p.3-13
Main Authors: Wu, Wei, Chung, Maxey C.M.
Format: Article
Language:English
Subjects:
Biomarker
biomarkers
biopsy
blood serum
death
Diagnosis
Gastric cancer
Gastric fluid
gastric juice
genome
new technology
patients
proteins
proteome
Proteomics
screening
stomach
stomach neoplasms
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Summary:Gastric cancer is a significant cause of death in many parts of the world. Although timely intervention is associated with better clinical outcome, early gastric cancer detection is frequently not possible given its asymptomatic nature. As such, sensitive and specific gastric cancer biomarkers are highly sought after as diagnostic surrogates that may replace invasive endoscopic and histological examinations. Unlike gastric cancer tissue and serum which are heterogeneous and overloaded with abundant proteins, the gastric fluid contains a concentrated molecular biopsy of the stomach that accurately reflects gastric oncology. This review attempts to (i) summarise the state of proteomics-based gastric cancer biomarker discovery from patient gastric fluids, (ii) outline key considerations in working with the body fluid, and (ii) discuss how the challenges in gastric cancer diagnosis may be overcome with new perspectives in gastric cancer screening. This article is part of a Special Issue entitled: From Genome to Proteome: Open Innovations. [Display omitted] •Reduction of gastric cancer mortality depends on non-invasive early detection.•Sensitive and specific gastric cancer biomarkers are in huge demand clinically.•Gastric fluid has been explored as a biomarker source using proteomics approaches.•Technological advancement should expand gastric fluid proteome coverage.•Biomarker validation and panel consideration may yield gastric cancer diagnostics.
ISSN:1874-3919
DOI:10.1016/j.jprot.2013.04.035