Histopathology of the intra-abdominal testis

PURPOSE Intra-abdominal undescended testes are associated with a high risk of infertility and cancer. The aim of this study was to evaluate the progression of germ cell damage in this sub-group of cryptorchid boys. MATERIAL AND METHODS The material included cryptorchid patients < 6 years at surge...

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Bibliographic Details
Published in:Journal of pediatric urology 2007, Vol.3, p.S39-S40
Main Author: Jorgen THORUP, Dina CORTES and Bodil LAUB PETERSEN
Format: Article
Language:English
Subjects:
Pediatrics
Urology
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Summary:PURPOSE Intra-abdominal undescended testes are associated with a high risk of infertility and cancer. The aim of this study was to evaluate the progression of germ cell damage in this sub-group of cryptorchid boys. MATERIAL AND METHODS The material included cryptorchid patients < 6 years at surgery (median 2.9 years) with operative biopsy and testicular tissue from 55 boys with intra-abdominal testes (20 bilateral) and 415 boys with cryptorchid testes in the inguinal canal or distal to this (117 bilateral). From the testicular biopsies the number of spermatogonia and gonocytes, if any/tubule (S/T) was measured and compared to a normal material. RESULTS Germ cells disappeared from 18-months of age. Hereafter, the frequency of no germ cells at surgery increased with increasing age (p
ISSN:1477-5131
1873-4898
DOI:10.1016/j.jpurol.2007.01.058