Relationship of apolipoprotein E polymorphism with lipid profiles in atherosclerotic coronary artery disease

The aim was to determine the relation of apolipoprotein E (ApoE) gene polymorphism with lipid profile in patients with coronary artery diseases (CAD) and its role in prediction of the severity of carotid and coronary atherosclerosis. One hundred patients were classified by coronary angiography: 80 p...

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Bibliographic Details
Published in:Journal Of The Saudi Heart Association 2012-10, Vol.24 (4), p.287-287
Main Authors: Elmadbouh, Ibrahim, Elghobashy, Yasser, Abd-Allah, Eman, Reda, Ashraf, Fathe, Adnan, Tayel, Safaa, Abd-Elhakim, Tarek
Format: Article
Language:English
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Summary:The aim was to determine the relation of apolipoprotein E (ApoE) gene polymorphism with lipid profile in patients with coronary artery diseases (CAD) and its role in prediction of the severity of carotid and coronary atherosclerosis. One hundred patients were classified by coronary angiography: 80 patients with CAD and 20 controls (normal coronary angiography). Clinical data, carotid sonography, blood lipid profiles and ApoE genotyping (PCR-RFLP) were assessed. CAD patients had significantly increased in plasma lipid profiles and carotid intimal-wall thickness (IMT) versus controls. In CAD patients, ApoE genotypes frequencies were E3/E3=62.50%, E2/E3=18.75%, E3/E4=17.50%, E2/E4=1.25%, E4/E4=0.0% and E2/E2=0.0%. But, E3/E4 genotype was significantly higher than controls (p
ISSN:1016-7315
2212-5043
DOI:10.1016/j.jsha.2012.06.233