Features of solid-phase mechanochemical synthesis of hydroxyapatite doped by copper and zinc ions

• Published in: Journal of solid state chemistry 2021-04, Vol.296, p.121973, Article 121973
• Main Authors: Bulina, Natalia V., Vinokurova, Olga B., Eremina, Natalia V., Prosanov, Igor Y., Khusnutdinov, Vyacheslav R., Chaikina, Marina V.
• Format: Article
• Language: English
• Subjects: Copper; Doping; Hydroxyapatite; Mechanochemical synthesis; Substitution; Zinc
• ISSN: 0022-4596; 1095-726X
• DOI: 10.1016/j.jssc.2021.121973

The work shows that single-phase hydroxyapatite doped with zinc or copper ions can be obtained using a solid-phase mechanochemical synthesis after 30 ​min of processing the reaction mixture in a planetary ball mill. To understand the mechanism of incorporating doping elements in the apatite structure, two substitution reactions have been investigated, namely replacement of the calcium and hydroxide ions with copper or zinc ions. The research has shown that, in the synthesized material, the dopant ions mainly take the sites of calcium ions. The degree of substitution can be up to 2 ​mol of substituent per mol of hydroxyapatite. The obtained samples can be used to produce medical bioresorbable items and coatings with antibacterial properties. The paper shows the possibility of solid-phase mechanochemical synthesis of hydroxyapatite doped by copper or zinc ions with a high degree of doping. [Display omitted] •A new approach to the synthesis of Cu/Zn-substituted apatites is proposed.•Dry mechanochemical method allows reducing the synthesis time down to 30 ​min.•The dopant ions mainly take the sites of calcium ions.•The degree of substitution can be up to 2 ​mol of substituent.