Effect of silicon-rich water intake on the systemic and peritoneal inflammation of rats with chronic low levels of aluminum ingestion

• Published in: Journal of trace elements in medicine and biology 2018-03, Vol.46, p.96-102
• Main Authors: Radovanovic, Zoran, Djindjic, Boris, Dzopalic, Tanja, Veljkovic, Andrej, Dunjic, Momir, Krstic, Dejan, Djindjic, Natasa, Nedeljkovic, Biljana Bozic
• Format: Article
• Language: English
• Subjects: Aluminum Chloride - administration & dosage; Aluminum Chloride - toxicity; Aluminum/toxicity; Animals; Cytokines - metabolism; Dietary Exposure - adverse effects; Drinking; Female; Food supply; Inflammation - chemically induced; Inflammation - metabolism; Lipopolysaccharides - pharmacology; Macrophage Activation; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - metabolism; Peritoneal macrophages; Rats, Wistar; Silicon; Silicon - pharmacology; Water; Water supply
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2017.12.001

Study evaluated effect of silicon-rich water intake on systemic inflammation and functional characteristics of peritoneal macrophages (PMs) of rats that were chronically exposed to dietary aluminum. One month-old female Wistar Albino rats were administered aluminum chloride dissolved in distilled water (1.6 mg/kg body weight in 0.5 mL) by gavage for 90 days. The rats were then given standard (6 mg/L) or silicon-rich water (19 mg/L silicon) (n = 7/group). Control rats underwent sham gavage and received standard or silicon-rich water (n = 7/group). Blood was assessed for cytokine levels. Unstimulated and lipopolysaccharide (LPS)-stimulated PMs were assessed in terms of phagocytic activity and cytokine secretion in vitro. Chronic exposition to dietary aluminum and silicon-rich drinking water did not change serum TNF-α levels. Aluminum increased serum IL-2 and this was reversed by silicon-rich water. The aluminum-exposed rats had higher serum sICAM-1 than sham-gavaged, unrelated to type of water. LPS-stimulated PMs from aluminum-intoxicated animals exhibited low phagocytic activity and release of TNF-α, this was significantly improved by silicon-rich water intake. In the presence of silicon-rich water, LPS-stimulated and unstimulated PMs from aluminum-exposed rats produced significantly more IL-10. Chronic ingestion of aluminum, increases systemic and peritoneal inflammation and PM dysfunction. The presence of high levels of the natural aluminum antagonist silicon in the drinking water restored IL-10 and TNF-α PM secretion, preventing prolonged inflammation. Thus, silicon intake can decrease the immunotoxicity of aluminum.