The neurotoxic impact of subchronic exposure of male rats to copper oxychloride

The target of this animal study was to clarify the influence of Copper oxychloride (COC) (at concentrations of 50, 100 and 200 mg/kg b.wt.) administration for ninety days on the brain tissues to evaluate its possible neurotoxicity. Thirty male albino rats were divided up into control and four experi...

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Bibliographic Details
Published in:Journal of trace elements in medicine and biology 2019-03, Vol.52, p.186-191
Main Authors: Gad El-Hak, Heba N., Mobarak, Yomn M.
Format: Article
Language:English
Subjects:
Cerebellum
Cerebral cortex
Copper oxychloride
LDH
Neurotoxicity
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Summary:The target of this animal study was to clarify the influence of Copper oxychloride (COC) (at concentrations of 50, 100 and 200 mg/kg b.wt.) administration for ninety days on the brain tissues to evaluate its possible neurotoxicity. Thirty male albino rats were divided up into control and four experimental groups. Group-II (rats were fed corn oil daily through oral gavage) and Group-III-A, Group-III-B, Group-III-C (rats were fed orally with COC in a dosage of 50 mg/kg, 100 mg/kg and 200 mg/kg b.wt., respectively, daily for ninety days. Various biochemical analyses and histopathological assessment of rat forebrain were investigated. the brains of the treated rats at the three chosen doses of COC recorded a significant (p≤0.05) elevation of lipid peroxidation. The measured brain lactate dehydrogenase (LDH) revealed non significant (p ≥  0.05) differences among the studied groups. Besides, there was a significant (p 
ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2018.12.015