Application of heart rate variability to determine physiologic changes in hypothermic rats

Time domain and power spectral density (PSD) analyses of ECG were used as indices of physiologic change in telemetry-equipped hypothermic rats. Anesthetized rats were either cooled (Hypo, Tc=20°C) and then rewarmed or maintained normothermic (NC). Heart rate, blood pressure, interbeat interval (IBI)...

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Bibliographic Details
Published in:Journal of thermal biology 2004-05, Vol.29 (4), p.237-243
Main Authors: Bastille, Amy M, Matthew, Candace B, Gonzalez, Richard R, Sils, Ingrid V, Hoyt, Reed W
Format: Article
Language:English
Subjects:
Autonomic nervous system
Central control of cardiac frequency
Heart rate
Hypothermia
Physiological monitoring
Rattus sp
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Summary:Time domain and power spectral density (PSD) analyses of ECG were used as indices of physiologic change in telemetry-equipped hypothermic rats. Anesthetized rats were either cooled (Hypo, Tc=20°C) and then rewarmed or maintained normothermic (NC). Heart rate, blood pressure, interbeat interval (IBI), normalized standard deviation (NSD) and PSD were determined. NSD in Hypo rats was significantly elevated at Tc=30°C which was coincident with the transition from increasing to decreasing HR and BP during cooling. With no change in PSD at Tc=30°C, the increased NSD suggests physiological events lacking an autonomic nervous system origin.
ISSN:0306-4565
1879-0992
DOI:10.1016/j.jtherbio.2004.02.007